Researchers now better understand ovarian cancer tumors and treatment outcomes

After nearly four years of work, a group of researchers and clinicians from the University of Colorado (CU) published a paper this week in the Clinical Cancer Research that shares findings from research looking at how the composition of ovarian cancer tumors changes during chemotherapy and contributes to therapeutic response. While the standard of care consisting of surgery and chemotherapy […]

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‘Deep dive’ into biology of kidney tumors identifies markers of response to immunotherapy

Treatments for kidney cancer have improved considerably over the past few decades. In 1988, when Memorial Sloan Kettering oncologist Robert Motzer started researching the disease, the average survival was less than one year. There were no approved therapies at the time besides surgery. By 2005, with the development of targeted drugs such as sunitinib (Sutent), survival nearly tripled. Today, with […]

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Attacking tumors from the inside

A new technology that allows researchers to peer inside malignant tumors shows that two experimental drugs can normalize aberrant blood vessels, oxygenation, and other aspects of the tumor microenvironment in non-small cell lung cancer (NSCLC), helping to suppress the tumor’s growth and spread, UT Southwestern researchers report. The findings, published online in Cancer Research, highlight the use of this novel […]

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Genome-wide pattern found in tumors from brain cancer patients predicts life expectancy

For the past 70 years, the best indicator of life expectancy for a patient with glioblastoma (GBM)—the most common and the most aggressive brain cancer—has simply been age at diagnosis. Now, an international team of scientists has experimentally validated a predictor that is not only more accurate but also more clinically relevant: a pattern of co-occurring changes in DNA abundance […]

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Developing sensors for tumors and dengue fever

Researchers from the International Islamic University Malaysia (IIUM) have developed a tumor biosensing chip that can help determine the optimum dosage of chemotherapy required for a cancer patient. Developed by Prof. Anis Nurashikin Nordin and her team, the miniature chip uses cells derived from cancer patients to screen reactions to different drugs and dosages. The sensor measures the growth and […]

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New classification system for tumors can guide diagnosis and treatment options for cancer

Based on the largest study of cancer patients of its kind, scientists have created a new way of classifying tumours. Clinicians can use genome sequencing to assign their patients’ tumours to one of sixteen groups in the new classification system, ten of which provide important information for the diagnosis and treatment of the disease, like whether an individual will respond […]

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New research suggests proton radiation can benefit pts with challenging liver tumors

Two new studies support and inform the use of proton radiation therapy to treat patients with hepatocellular carcinoma (HCC), a common but often fatal type of liver cancer for which there are limited treatment options. One study (Sanford et al.) suggests that proton radiation, compared to traditional photon radiation, can extend overall survival with reduced toxicity. A second study (Hsieh […]

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Therapy for neuroendocrine tumors may be improved by patient-specific dosimetry

In neuroendocrine tumor treatment, different methods of predicting patient response may be required for different patients, according to new research published in the October issue of The Journal of Nuclear Medicine. By tailoring the method to the specific patient, physicians may better predict the effectiveness of treatment. “The present study aimed to develop a method for patient-specific determination of activity […]

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A new approach to targeting tumors and tracking their spread

The spread of malignant cells from an original tumor to other parts of the body, known as metastasis, is the main cause of cancer deaths worldwide. Early detection of tumors and metastases could significantly improve cancer survival rates. However, predicting exactly when cancer cells will break away from the original tumor, and where in the body they will form new […]

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Antibody therapy training phagocytes to destroy tumors now tested on patients

Developed by researchers at the University of Turku in Finland, an immunotherapeutic antibody therapy re-educates macrophages to activate passivated cytotoxic T cells to kill cancer. The antibody therapy prevented the growth of tumours in several mouse models, and the development of the therapy has now progressed to patient testing in a phase I/II clinical trial. One reason behind many unsuccessful […]

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