Clinical trial suggests convalescent plasma may improve survival with severe COVID-19

A randomized double-blind controlled trial of convalescent plasma for adults hospitalized with severe COVID-19 found that mortality at 28 days in the treatment arm was half the rate seen in the control arm (12.6% vs. 24.6%), although treatment was not associated with other improvements in clinical status. The study was led by investigators from the Center for Infection and Immunity […]

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Clinical trial: Using MRI for prostate cancer diagnosis equals or beats current standard

The results of a Phase III randomized clinical trial have shown that when it comes to detecting clinically significant prostate cancer, Magnetic Resonance Imaging (MRI) with targeted biopsies (MRI-TBx) matches the current standard and brings a multitude of advantages. The PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures (PRECISE) study will help to make prostate cancer diagnosis […]

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INOVIO Doses First Subject in Phase 2 Segment of its INNOVATE Phase 2/3 Clinical Trial for INO-4800, its DNA Medicine to Prevent COVID-19

PLYMOUTH MEETING, Pa., Dec. 7, 2020 /PRNewswire/ — INOVIO (NASDAQ: INO), a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases and cancer, today announced it has dosed its first subject in a Phase 2 clinical trial evaluating DNA medicine INO-4800, its COVID-19 vaccine candidate, as part of its Phase 2/3 clinical […]

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Eli Lilly ends antibody trial early after failed to help in recovery

Eli Lilly ends paused trial of antibody drug and remdesivir after the NIH found the combo failed to help recovery of hospitalized patients  Eli Lilly & Co and the National Institues of Health announced they are ending a clinical trial of antibody drug The study was looking at a combination of the antibody, LY-CoV555, and remdesivir as a treatment for hospitalized coronavirus […]

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Scientists to Infect Volunteers With COVID-19 in Challenge Trial

TUESDAY, Oct. 20, 2020 — British scientists are infecting healthy volunteers with COVID-19, in hopes of speeding up vaccine development, TheWashington Postreported Tuesday. Led by scientists at Imperial College London, people in this challenge trial will be guaranteed treatment if they become ill. The United States says human challenge trials might be too risky or unnecessary. But for the British, […]

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NIH Launches Trial of Antibody Drugs Against COVID-19

WEDNESDAY, Oct. 14, 2020 — A study to assess whether certain approved or experimental drugs are effective against COVID-19 and warrant testing in large clinical trials has been launched by the U.S. National Institutes of Health (NIH). The research will largely focus on monoclonal antibody medications. These types of drugs garnered headlines last week as President Donald Trump credited one […]

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Medical trial meets one primary endpoint in heart failure with preserved ejection fraction

Sacubitril/valsartan reduces NT-proBNP, a biomarker predictive of long-term clinical outcomes in heart failure, but does not improve functional capacity compared to individualized background therapy in patients with heart failure with preserved ejection fraction. That’s the main finding of the PARALLAX trial presented in a Hot Line session today at ESC Congress 2020. Heart failure with preserved ejection fraction (HFpEF) affects […]

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