Targeting MAPK4 emerges as a promising therapy for prostate cancer

The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease. Research led by Baylor College of Medicine reveals in the Journal of Clinical Investigation that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance […]

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Potential combined drug therapy for lung cancer

Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment. Alectinib is a drug commonly used for treating patients with NSCLC. It addresses a gene rearrangement known as ALK that occurs in 3 to 5% of NSCLC patients (alectinib belongs […]

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Novel therapy approach for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine. The novel approach utilizes receptor-targeted photodynamic therapy with exendin-4-IRDye700DX to induce phototoxicity in insulin-producing cells that cause hyperinsulinemic hypoglycemia. Insulin production by pancreatic beta cells is […]

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Study reveals restoration of retinal and visual function following gene therapy

A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease. Published today in Nature Biomedical Engineering, the paper, titled, “Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing,” illustrates the use of a new […]

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What’s up doc? Donkey therapy eases Spain medics’ stress

Walking into a dusty paddock, a young nurse is quickly surrounded by a group of donkeys gently nudging her for attention as she strokes their soft noses and feeds them carrots. When someone places a 10-day-old colt in her arms, Monica Morales squeals with delight, visibly relaxed after a few hours unwinding at El Burrito Feliz—”The Happy Little Donkey”— an […]

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New technique for ultrafast tumor therapy

For the first time, researchers at the Center for Proton Therapy at the Paul Scherrer Institute PSI in Switzerland have tested ultrafast, high-dose irradiation with protons. This new, experimental FLASH technique could revolutionize radiation therapy for cancer and save patients many weeks of treatment. In nature, lightning strikes with a short, strong flash of light and a high energy discharge. […]

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Study examines women’s attitudes toward long-acting injectable therapy to prevent HIV

Oral pre-exposure prophylaxis (PrEP) is a highly effective method of reducing risk for HIV, yet use of PrEP is uniformly low, especially among women. As a result, researchers have developed long-acting injectable (LAI) versions of PrEP, one version of which was recently shown to be superior to oral PrEP in Phase 3 trials. A new study among women at high […]

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Benefits of inhaled nitric oxide therapy for pregnant patients with COVID-19

Inhaled nitric oxide (NO) can be a valuable adjunct respiratory therapy for pregnant women with severe and critical COVID-19, a team of researchers from Massachusetts General Hospital (MGH) has found. The delivery of the therapeutic gas to six COVID-19 pregnant patients admitted to MGH, as described in a paper in Obstetrics & Gynecology, resulted in a rapid and sustained improvement […]

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CAR T cell therapy: Potential for considerable savings

Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: The manufacturers charge up to EUR 320,000 for the production of immune cells for a single patient. By determining the fixed […]

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