First specific drug therapy for a severe early form of epilepsy

Epilepsy comes in a variety of forms. Those affected by a genetically determined variety have severe epileptic seizures as early as the first year of life. The disease is accompanied by severe developmental disorders: it is difficult for them to walk, they have difficulty concentrating and later have problems with speech, spelling and calculations. Until now, this form of epilepsy […]

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Tailoring exercise therapy to individual heart failure patients

While exercise therapy for heart failure (HF) patients with low heart function has been shown to be an effective prognostic tool, the level and format of exercise that yields optimal effects is still unclear. In a study to understand how exercise-induced oxidative stress affects patients with HF, researchers from the Osaka City University (OCU) Graduate School of Medicine have shown […]

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Games as therapy for people with language loss

In a year when many of us worked virtually, a small group gathered online with the common goal of making speech and language therapy more accessible—while having some fun along the way. Their project, called Aphasia Games for Health, focused on producing games that can provide therapeutic benefits for people with aphasia—a language disorder that can affect speaking, comprehension, reading […]

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Tailor-made therapy of multi-resistant tuberculosis

Globally, tuberculosis is the most common bacterial infectious disease leading to death. The pathogen causing tuberculosis, Mycobacterium tuberculosis, has a number of peculiarities. One is that it is growing very slowly. While other typical pathogens, such as pneumococcal and pseudomonads, can already be identified by their growth in the microbiological laboratory in the first 72 hours, several weeks usually pass […]

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Targeting MAPK4 emerges as a promising therapy for prostate cancer

The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease. Research led by Baylor College of Medicine reveals in the Journal of Clinical Investigation that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance […]

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Potential combined drug therapy for lung cancer

Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment. Alectinib is a drug commonly used for treating patients with NSCLC. It addresses a gene rearrangement known as ALK that occurs in 3 to 5% of NSCLC patients (alectinib belongs […]

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Novel therapy approach for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine. The novel approach utilizes receptor-targeted photodynamic therapy with exendin-4-IRDye700DX to induce phototoxicity in insulin-producing cells that cause hyperinsulinemic hypoglycemia. Insulin production by pancreatic beta cells is […]

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Study reveals restoration of retinal and visual function following gene therapy

A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease. Published today in Nature Biomedical Engineering, the paper, titled, “Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing,” illustrates the use of a new […]

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What’s up doc? Donkey therapy eases Spain medics’ stress

Walking into a dusty paddock, a young nurse is quickly surrounded by a group of donkeys gently nudging her for attention as she strokes their soft noses and feeds them carrots. When someone places a 10-day-old colt in her arms, Monica Morales squeals with delight, visibly relaxed after a few hours unwinding at El Burrito Feliz—”The Happy Little Donkey”— an […]

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