The price of a drug should be based on its therapeutic benefits – not just what the market will bear

The U.S. pharmaceutical industry has innovated in response to the pandemic, providing not only vaccines but also therapies to treat people with COVID-19. But an outdated law designed to spur development of lifesaving drugs risks making new treatments—for COVID-19 as well as other diseases—unaffordable for many Americans. Many pharmaceutical companies rely on the Orphan Drug Act, which President Ronald Reagan […]

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Alternative cancer cell fuel source targeted as therapeutic approach for breast cancer

Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in conditions of low nutrient and oxygen availability. This molecule caused tumor growth inhibition and regression in preclinical studies, demonstrating the promise of this approach as a novel therapeutic strategy for solid tumors. Study results were […]

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Engineering lymphatic vessels as a therapeutic to heal the heart

The cardiovascular system is a complex network of veins, arteries and capillaries. Within that network, lymphatic vessels are critical to the heart’s ability to heal in the event of a heart attack. When they’re functional, lymphatic vessels drain excess fluid that can cause swelling, and carry immune cells that can regulate inflammation and fight infection—each of which are a potential […]

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Building therapeutic cities to tackle mental health problems

In all likelihood, poor mental health has blighted every age of human existence. Evolutionary psychologists suggest it may be an intrinsic, even necessary, condition for our species. But there are grounds to suppose that we are now witnessing a rise in conditions such as stress, anxiety, depression, burnout and suicide, as mental health disorders are measured to have a growing […]

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