Vaccinated Hawaiian resident tests positive for Delta coronavirus variant

Doctors urge COVID vaccinations as Delta variant spreads Fox News medical contributor Dr. Marty Makary discusses the COVID-19 Delta variant and vaccine side-effects in adolescents Hawaiian health officials said Monday that a fully vaccinated resident who traveled to Nevada last month has since tested positive for the Delta coronavirus variant. The resident, who lives in Oahu, tested negative for COVID-19 […]

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New class of drug gives hope to some ovarian cancer patients

A study published today in Nature Communications shows that the drug rucaparib has been effective in treating certain types of ovarian cancers if used early in treatment, after a diagnosis, and before the cancer cells build up a resistance to chemotherapy. Rucaparib is in a relatively new class of drugs—Poly(ADP-ribose) polymerase or PARP inhibitors—which have been approved for therapy in ovarian cancers. […]

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Fighting Zika? Call in the T cells

Where Aedes mosquitoes fly, Zika virus may not be far behind. Although the explosive 2015-2016 Zika epidemics in the Americas are behind us, Zika may re-emerge, and “in many countries, Zika may be spreading in silence,” says Sujan Shresta, Ph.D., a professor at La Jolla Institute for Immunology (LJI). “We need to develop effective vaccines.” In a new Science Advances […]

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Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function

Ultraviolet B (UVB) is used as an effective therapy for individuals with psoriasis and atopic dermatitis because it has an immunosuppressive effect. The immune system develops to protect the body from infection or cancer. Its activation affects many physiological functions. Regulatory T (Treg) cells, expressing CD25 and Foxp3, constitute about 5-10% of peripheral CD4+T cells and work as brake on […]

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CAR T cell therapy: Potential for considerable savings

Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: The manufacturers charge up to EUR 320,000 for the production of immune cells for a single patient. By determining the fixed […]

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Denver opens new coronavirus testing sites to reach underserved populations

Denver public health officials are offering free testing for the novel coronavirus in new locations to reach underserved populations as the pandemic highlights racial inequalities. People of color are seeing higher infection rates of COVID-19, while black Coloradans have died from the disease caused by the new coronavirus at a disproportionately high rate. The city already offers free drive-up, testing […]

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Medical intelligence sleuths tracked, warned of new coronavirus – The Denver Post

WASHINGTON — In late February when President Donald Trump was urging Americans not to panic over the novel coronavirus, alarms were sounding at a little-known intelligence unit situated on a U.S. Army base an hour’s drive north of Washington. Intelligence, science and medical professionals at the National Center for Medical Intelligence were quietly doing what they have done for decades […]

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New Insights: Armies of strategically stationed T cells fight viral infections, cancer

The immune system mounts robust responses to infections, vaccines and cancer, but only now have scientists fully begun to unravel how non-circulating populations of T cells that reside in the body’s “mucosal barrier tissues” keeps threats at bay. While an academic focus on non-circulating T cells in mucosal tissues may seem like an arcane area of research, it is the […]

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Engineered T cells may be harnessed to kill solid tumor cells

There is now a multitude of therapies to treat cancer, from chemotherapy and radiation to immunotherapy and small molecule inhibitors. Chemotherapy is still the most widely used cancer treatment, but chemotherapy attacks all the rapidly dividing cells that it locates within the body, whether they’re ultimately harmful or beneficial. A new Tel Aviv University study led by Dr. Yaron Carmi […]

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Immunologists identify T cell homing beacons for lungs

Scientists have identified a pair of molecules critical for T cells, part of the immune system, to travel to and populate the lungs. A potential application could be strengthening vaccines against respiratory pathogens such as influenza. The findings were published online Thursday, September 26 in Journal of Experimental Medicine. Much research on immunity to influenza virus focuses on antibodies, infection- […]

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