CAR T cell therapy: Potential for considerable savings

Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: The manufacturers charge up to EUR 320,000 for the production of immune cells for a single patient. By determining the fixed […]

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Denver opens new coronavirus testing sites to reach underserved populations

Denver public health officials are offering free testing for the novel coronavirus in new locations to reach underserved populations as the pandemic highlights racial inequalities. People of color are seeing higher infection rates of COVID-19, while black Coloradans have died from the disease caused by the new coronavirus at a disproportionately high rate. The city already offers free drive-up, testing […]

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Medical intelligence sleuths tracked, warned of new coronavirus – The Denver Post

WASHINGTON — In late February when President Donald Trump was urging Americans not to panic over the novel coronavirus, alarms were sounding at a little-known intelligence unit situated on a U.S. Army base an hour’s drive north of Washington. Intelligence, science and medical professionals at the National Center for Medical Intelligence were quietly doing what they have done for decades […]

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New Insights: Armies of strategically stationed T cells fight viral infections, cancer

The immune system mounts robust responses to infections, vaccines and cancer, but only now have scientists fully begun to unravel how non-circulating populations of T cells that reside in the body’s “mucosal barrier tissues” keeps threats at bay. While an academic focus on non-circulating T cells in mucosal tissues may seem like an arcane area of research, it is the […]

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Engineered T cells may be harnessed to kill solid tumor cells

There is now a multitude of therapies to treat cancer, from chemotherapy and radiation to immunotherapy and small molecule inhibitors. Chemotherapy is still the most widely used cancer treatment, but chemotherapy attacks all the rapidly dividing cells that it locates within the body, whether they’re ultimately harmful or beneficial. A new Tel Aviv University study led by Dr. Yaron Carmi […]

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Immunologists identify T cell homing beacons for lungs

Scientists have identified a pair of molecules critical for T cells, part of the immune system, to travel to and populate the lungs. A potential application could be strengthening vaccines against respiratory pathogens such as influenza. The findings were published online Thursday, September 26 in Journal of Experimental Medicine. Much research on immunity to influenza virus focuses on antibodies, infection- […]

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CAR T cell therapy: On the cusp of ‘an immunotherapy revolution’?

A deeper understanding of the immune system’s role in controlling cancer has helped drive “an immunotherapy revolution,” offering hope for many patients with previously incurable cancers, including children, doctors have concluded in a new report. The assessment, from two Stanford University doctors, is part of their broader analysis on lessons learned from “the first leg of the CAR T cell […]

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New evidence shows cytotoxic T cells can identify, invade, and destroy targets of large mass like T. gondii tissue cysts

CD8+ cytotoxic T lymphocytes can kill host cells infected with various microorganisms as well as single individual cancer cells through direct cell-to-cell contact, but their ability to destroy a target of large mass remains unexplored. A study in The American Journal of Pathology provided novel evidence on the capability of the immune system to eliminate large parasite-filled cysts associated with […]

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Reducing B cells with CAR T cells is effective treatment of experimental lupus

Depleting the number of harmful B cells with a novel immunotherapy that employs modified T cells may offer an effective strategy to treat lupus, according to a new study funded by the Lupus Research Alliance. These findings offer a renewed optimism for the elimination of B cells to provide a therapeutic option in lupus and pave the way for clinical […]

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