Chemical cocktail creates new avenues for generating muscle stem cells

A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells. The advance could lead to the development of stem cell-based therapies for muscle loss or damage due to injury, age or disease. The research was published in […]

Read more

Bone marrow ‘map’ opens path to organoid-like blood stem cell production

Imagine a day when clinicians treating people with blood diseases such as leukemia or multiple myeloma can send in requests for laboratories to custom-produce specific types of blood cells to replace those affected by the disease. That day became one step closer to reality with a new study led by experts at Cincinnati Children’s that provides powerful new insights into […]

Read more

Researchers create human airway stem cells from patients’ cells

For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium in response to injury, this study may help accelerate research on diseases impacting the […]

Read more

Adult stem cells/glaucoma drug combo promotes diabetic wound healing in mice

A new study released today in Stem Cells Translational Medicine shows promise of a major breakthrough in healing chronic foot ulcers resulting from diabetes. The study, by researchers at the University of California, Davis, is the first to demonstrate how a bioengineered scaffold made up of human mesenchymal stem cells (MSCs) combined with timolol—a drug commonly used to treat glaucoma—improved […]

Read more

Austrian ski resorts shutting down to stem virus

Credit: CC0 Public Domain World-class ski areas in western Austria’s Tyrol province are to close down Sunday to fight the spread of the new coronavirus, regional officials said Thursday. Tyrol shares a border with Italy and is one of the places where Austrian cases of COVID-19, the disease caused by the virus, have been concentrated. “The decision was not easy […]

Read more

Stem cells with ‘dual identity’ linked to loss of smell from sinus inflammation

In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis. Results of the study, they say, suggest that the stem cells’ ability to switch their identity to join in the […]

Read more

Michael Schumacher’s stem cell surgery is ‘experimental’, doctor says

Could pioneering stem cell treatment offer hope for Michael Schumacher? How French surgeon drafted in for a ‘secret operation’ is at the forefront of the experimental procedure being tested on heart failure It is understood the German will be operated on by a heart specialist in Paris The procedure is thought to involve grafting stem cells onto damaged tissue An […]

Read more

Mini-kidneys grown from stem cells provide new insights into kidney disease and potential therapies

An international team of researchers led by Nanyang Technological University, Singapore (NTU Singapore) has grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. The mini kidneys, known as kidney organoids, were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease, one […]

Read more

Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. It’s the first time that scientists have specifically edited the genetic makeup of a specialized subset […]

Read more
1 2