SARS-CoV-2 immunization passports: A ticket to normal life?

Proof of immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may soon be required in many parts of the globe. The authors discuss how immunization passports could work, what Canada needs to do, and potential barriers and limitations in a CMAJ (Canadian Medical Association Journal) commentary. “We expect that immunization passports may be imminently introduced for international travel,” writes […]

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Single-dose of BNT162b2 vaccine may not be protective without prior SARS-CoV-2 infection

Vaccine rollouts in many countries are bringing hope that the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), will come to an end in the foreseeable future. Several vaccines have shown high protective efficacy against SARS-CoV-2 infection or severe disease. Study: Effect of previous SARS-CoV-2 infection on humoral and T-cell responses to single-dose […]

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SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation. Moreover, they observe that the severity of coronavirus disease 2019 (COVID-19) primarily depends on the blood […]

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Antibody and T cell response to SARS-CoV-2 persist up to 8 months: Study of Ski Resort Ischgl

The first instance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Austria was observed in the Ski resort Ischgl in early March 2020. Later, the virus spread across Austria and other countries in Northern Europe. Researchers conducted a cross-sectional study to gauge the seroprevalence of SARS-CoV-2 in the population, as measured in the blood serum. They found […]

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UK and South African SARS-CoV-2 variants show higher binding affinity to host cell receptor

Public health officials are concerned over new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerging in various parts of the world. The B.1.1.7 variant was first found in the United Kingdom and found to have the N501Y mutation that allows it to have a faster transmission rate than previous strains. The B.1.351 variant was detected in South Africa and […]

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Countries with older populations have higher SARS-CoV-2 infections and deaths, says study

More than a year into the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the difference in the severity of the clinical syndrome by country-wide income levels has become clear. A new preprint, released on the medRxiv* server, examines some patterns revealed by a study of the factors operating in different regions and […]

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HSE researchers discover genetic predisposition to COVID-19 severity

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology. T-cell immunity is one of the key mechanisms used by the human body to fight virus infections. The staging ground for cell immunity development is the presentation of virus peptides […]

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SARS-CoV-2 DNA vaccine tested in animal model

Vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being rolled out worldwide to control the COVID-19 (coronavirus disease 2019) pandemic. Multiple vaccines are necessitated to address the variant epidemics and also overcome the challenges that may be posed by the current vaccines (such as high cost, or low immunogenicity). In this context, a team of experts has […]

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Bats and pangolins in Southeast Asia harbor SARS-CoV-2-related coronaviruses, study finds

The sudden and devastating emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the etiological agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic – has raised many questions as to where it came from. The possibility of potential animal viral reservoirs, as evidenced by the ready transmission of the virus to mink and back again to mink […]

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The origin of SARS-CoV-2 furin cleavage site remains a mystery

The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has largely defied attempts to contain its spread by non-pharmaceutical interventions (NPIs). With the massive loss of life and economic damage, the only way out, in the absence of specific antiviral therapeutics, has been the development of vaccines to achieve population immunity. […]

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