UK and South African SARS-CoV-2 variants show higher binding affinity to host cell receptor

Public health officials are concerned over new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerging in various parts of the world. The B.1.1.7 variant was first found in the United Kingdom and found to have the N501Y mutation that allows it to have a faster transmission rate than previous strains. The B.1.351 variant was detected in South Africa and […]

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HSE researchers discover genetic predisposition to COVID-19 severity

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology. T-cell immunity is one of the key mechanisms used by the human body to fight virus infections. The staging ground for cell immunity development is the presentation of virus peptides […]

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SARS-CoV-2 DNA vaccine tested in animal model

Vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being rolled out worldwide to control the COVID-19 (coronavirus disease 2019) pandemic. Multiple vaccines are necessitated to address the variant epidemics and also overcome the challenges that may be posed by the current vaccines (such as high cost, or low immunogenicity). In this context, a team of experts has […]

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Guilak recognized for research in cartilage engineering

Farshid Guilak, PhD, the Mildred B. Simon Research Professor of Orthopaedic Surgery and co-director of the Washington University Center of Regenerative Medicine, has received the 2021 Elizabeth Winston Lanier Kappa Delta Award for his research involving the treatment of arthritic joints, growing cartilage from patients’ donor cells and seeding them on a scaffold to create a living joint replacement as […]

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Research calculates the years of life lost to COVID-19 in 81 countries

Research published in the journal Scientific Reports, with prominent participation by the Centre for Research in Health and Economics (CRES-UPF) and the Max Planck Institute for Demographic Research, has calculated the years of life lost (YLL) rate due to the pandemic in 81 countries. The major direct and indirect effects of covid-19 have forced the authorities to implement policies that […]

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Bats and pangolins in Southeast Asia harbor SARS-CoV-2-related coronaviruses, study finds

The sudden and devastating emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the etiological agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic – has raised many questions as to where it came from. The possibility of potential animal viral reservoirs, as evidenced by the ready transmission of the virus to mink and back again to mink […]

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Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body's glucose levels, which is important for the development of metabolic diseases like diabetes. In a recent study, published in The Journal of Clinical Investigation, […]

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Scientists discover two unique subtypes of a prominent mutation in patients with AML

Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) – called NPM1 – that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation. In research published Feb. 16, in Nature Communications, a team led by Princess Margaret Cancer Centre […]

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Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome

Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia? The question remained a mystery for decades, but in a paper published today in Translational Psychiatry, researchers from the University of Pittsburgh School of Medicine finally cracked the enigma. Antipsychotic drugs, scientists showed, not only block dopamine signaling in […]

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