3D lab skin for chemicals testing, research and repair

A model system that recreates full-thickness human skin should allow more effective testing of pharmaceuticals and cosmetics, while avoiding the need for animal tests. The system effectively models the development, cellular structure and barrier properties of skin. This should also make it suitable for analyzing disease states and wound repair processes. Another potential use is as a substrate for repairing […]

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Study suggests sugary diet endangers waste-eating protein crucial to cellular repair

A protein that functions like the vintage video game Pac-Man, eating toxic cellular waste caused by high sugar intake, is itself compromised by a sugary diet, according to the results of a study in mice with potential implications for humans. The study, led by a research team at Tufts University joined by researchers at eight other institutions, appears in Aging […]

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Study shows nervous and immune systems ‘need to talk’ for bone repair

In a December 2019 study, a team of Johns Hopkins Medicine researchers demonstrated in mice that repair of bone fractures requires the generation, growth and spread of nerve cells, or neurons, throughout the injured area. This, they showed, partly relies on a protein known as nerve growth factor (NGF). Now, the researchers have dug deeper into this process to better […]

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Imaging nerve regeneration provides insight to success of repair

When peripheral nerves are injured and surgically repaired, regeneration must occur in a timely fashion to restore sensory and motor function. Current methods for following nerve regeneration provide only limited information and may delay a needed second surgical intervention and lead to poor outcomes. Richard Dortch, Ph.D., (Radiology and Radiological Sciences), Wes Thayer, MD, Ph.D., (Plastic Surgery), and colleagues evaluated […]

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The night gardeners: Immune cells rewire, repair brain while we sleep

Science tells us that a lot of good things happen in our brains while we sleep—learning and memories are consolidated and waste is removed, among other things. New research shows for the first time that important immune cells called microglia—which play an important role in reorganizing the connections between nerve cells, fighting infections, and repairing damage—are also primarily active while […]

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