Researchers identify faulty ‘brake’ that interferes with heart muscle’s ability to contract and relax

Hypertrophic cardiomyopathy (HCM) is the most common genetic disease of the heart and a leading cause of sudden cardiac death in young people and athletes. Scientists have long known that the condition’s cardinal feature—an unusually thick heart muscle that contracts and relaxes abnormally—is fueled by some glitch in the heart’s molecular machinery. Yet, the sparkplug that ignites such disordered muscle […]

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