Another promising approach for hard-to-treat blood cancers

For patients with some hard-to-treat blood cancers, a simple “off-the-shelf” immunotherapy is achieving promising results. A clinical trial of the developmental drug Glofitamab has shown it can produce a durable “complete response”—meaning the cancer became undetectable—in patients with relapsed or treatment resistant B-cell lymphomas. One option for these patients is CAR T-cell therapy—also an immunotherapy but one which involves collecting […]

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Another promising approach for hard-to-treat blood cancers

For patients with some hard-to-treat blood cancers, a simple “off-the-shelf” immunotherapy is achieving promising results. A clinical trial of the developmental drug Glofitamab has shown it can produce a durable “complete response”—meaning the cancer became undetectable—in patients with relapsed or treatment resistant B-cell lymphomas. One option for these patients is CAR T-cell therapy—also an immunotherapy but one which involves collecting […]

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Targeting MAPK4 emerges as a promising therapy for prostate cancer

The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease. Research led by Baylor College of Medicine reveals in the Journal of Clinical Investigation that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance […]

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Novel principle for cancer treatment shows promising effect

Researchers at Karolinska Institutet in Sweden report in the journal Nature that they have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumor growth in mice without significantly affecting healthy cells. “We are excited to have shown that this novel principle for cancer treatment works in […]

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More evidence that cellular ‘death by iron’ could be promising avenue of cancer treatment

If there is a silver lining in cancer’s chaotic biology, it’s that the same traits that give cancer cells a growth advantage often present opportunities for sabotaging them. That’s the central idea behind a new research paper published November 23 in Proceedings of the National Academy of Sciences (PNAS) by Xuejun Jiang, a cell biologist in the Sloan Kettering Institute, […]

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Researchers find promising new treatment approach for multiple sclerosis

In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report. The findings, published online today by Science Translational Medicine, could lead to a new treatment strategy for this neurological disease and other conditions marked […]

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Promising pre-clinical results for COVID-19 vaccine

A COVID-19 vaccine candidate developed by the University of Saskatchewan’s (USask) Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) has cleared another major milestone in moving towards human clinical trials: the novel vaccine has proven highly effective in ferrets, one of the commonly used animal models for COVID-19. To evaluate the effectiveness of the vaccine, the ferrets received two immunizations […]

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Study shows promising new web approach to prevent firearm suicide

Access to firearms and other lethal methods of suicide during periods of risk can make it more likely that a suicide attempt will end in death. Yet many patients with suicidal thoughts or behaviors receive no counseling about this from healthcare providers, and many have questions about options for firearm or medication storage. To address the issue, clinicians and researchers […]

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Promising molecule targets protein to offer hope for people with Parkinson’s

Results from a study published today looking at a molecule targeting clumps of alpha-synuclein, a key protein linked to Parkinson’s, offers hope that it may be possible to slow down or prevent the progression of the condition in humans. Researchers at the University of Cambridge have been able to investigate the effect of a molecule called anle138b, by developing a […]

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Researchers uncovers promising cancer target for liposarcoma

A study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed a close association between liposarcoma (LPS), a type of cancer that develops from fat cells, and the bromodomain and extraterminal (BET) protein family. In the study recently published in prestigious scientific journal, Nature Communications, in […]

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