Vaccine development software shows promise in influenza effort, could help defeat coronavirus

A novel computer algorithm that could create a broadly reactive influenza vaccine for swine flu also offers a path toward a pan-influenza vaccine and possibly a pan-coronavirus vaccine as well, according to a new paper published in Nature Communications. “This work takes us a step closer to a pan-swine flu virus vaccine,” said Bette Korber, a computational biologist at Los […]

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Home-visiting program shows promise of reducing risk of obesity among Native American children

Lessons on healthy feeding practices delivered to young mothers through a brief home-visiting intervention put Native American infants on a healthier growth trajectory, lowering their risks for obesity, according to a study from researchers at the Johns Hopkins Center for American Indian Health at the Bloomberg School of Public Health. Prior research suggests that adult obesity, which is linked to […]

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Targeted inhibitor of mutated KRAS gene shows promise in lung, bowel, other solid tumors

A novel agent that targets a mutated form of the KRAS gene—the most commonly altered oncogene in human cancers and one long considered “undruggable”—shrank tumors in most patients in a clinical trial with manageable side effects, researchers reported today at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Therapeutic, which is taking place online. The KRYSTAL-1 (NCT03785249) phase I/II trial […]

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Dynamic tattoos promise to warn wearers of health threats

In the sci-fi novel “The Diamond Age” by Neal Stephenson, body art has evolved into “constantly shifting mediatronic tattoos”—in-skin displays powered by nanotech robopigments. In the 25 years since the novel was published, nanotechnology has had time to catch up, and the sci-fi vision of dynamic tattoos is starting to become a reality. The first examples of color-changing nanotech tattoos […]

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Radiation/immunotherapy combo shows promise for recurrent/metastatic head and neck cancers

A new phase II trial finds that a combination of radiation therapy and immunotherapy led to encouraging survival outcomes and acceptable toxicity for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). The combination of radiation and pembrolizumab may offer a new treatment option for patients who are ineligible for cisplatin chemotherapy, part of standard treatment for the […]

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Drug combination shows promise in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone. Hollings Cancer Center scientists at the Medical University of South Carolina reported these findings in PLOS ONE. TNBC disproportionately affects African […]

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Long-acting injectable multi-drug implant shows promise for HIV prevention and treatment

A new study published today in Nature Communications shows a promising alternative for those who have to take a daily pill regimen. Targeting HIV treatment and prevention, researchers across multiple departments at the University of North Carolina at Chapel Hill collaborated on a seven-year study in animals to make a better injectable drug implant that can combine multiple drugs and […]

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Remedy for sleep disorders often superfluous or even risky

Consumer advocates: effect of the products against insomnia doubtful Million people in Germany suffer from sleep disorders. Too little sleep not only ensures that those Affected are during the day, mostly tired, but also is a risk to health. The use of over-the-counter remedies to promote better sleep, is not usually recommended nevertheless. Some of these drugs can even be […]

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Sutimlimab shows promise for hard-to-treat, rare blood disorder

In a first-in-human clinical trial reported today in Blood, the investigational drug sutimlimab appeared to be effective in treating cold agglutinin disease, a rare chronic blood disorder for which there are currently no approved treatments. Cold agglutinin disease is caused by a malfunction in the immune system that causes antibodies—components of the immune system that are produced in the blood […]

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