One’s internal clock could be targeted to prevent or slow the progression of breast cancer

City of Hope scientists have identified an unlikely way to potentially prevent or slow the progression of aggressive breast cancer: target one’s internal clock. Often taken for granted, the circadian rhythm is gaining traction as a potential catalyst or brake for the onset of disease. For example, studies have shown that women who take frequent night shifts have disrupted internal […]

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Blood-clotting protein and blood platelets promote immune evasion, cancer progression

A new study led by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) reveals how a clotting protein and blood platelets can promote cancer progression and suppress immune responses to cancer. The findings show how thrombin, a clotting protein in the blood, causes blood platelets to release transforming […]

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Epigenetic markers reveal tumor progression and metastasis in multiple cancer types

New University of Otago research into tell-tale markers of cancer cells could help doctors identify whether the cells are more likely to spread to other parts of the body. The impact of that knowledge could give doctors and patients a clearer idea of how aggressively the cancer cells spread and therefore inform treatment options. The research was published this week […]

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Branched-chain amino acids regulate the development and progression of cancer

Researchers at A*STAR’s Singapore Bioimaging Consortium (SBIC) have discovered that branched-chain amino acids (BCAAs) in tumours can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore (NCCS), they found that some cancers potently suppress the catabolism (breakdown) of BCAAs. This leads to BCAAs accumulating in tumours and activating a known […]

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