New Parkinson’s disease therapeutics discovered

Ben-Gurion University of the Negev researchers have discovered that the protein BMP5/7 offers promising therapeutics that could slow down or halt the progression of Parkinson’s disease. The findings were published in the clinical neurology journal Brain. Parkinson’s disease, which affects over 1 million people in the U.S. and 10 million worldwide, causes tremors and severe movement impairment due to progressive […]

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Faulty metabolism of Parkinson’s medication in the brain linked to severe side effects

Until now, the reason why the drug levodopa (L-Dopa), which reduces the motor symptoms of Parkinson’s disease, declines in efficacy after a few years’ use has been unknown. A side effect that then often occur is involuntary movements. A Swedish–French collaboration, led from Uppsala University, has now been able to connect the problems with defective metabolism of L-Dopa in the […]

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The impact of COVID-19 on access to Parkinson’s disease medication

A global survey of health professionals, led by Queen Mary University of London, has shown that during the COVID-19 pandemic, patients with Parkinson’s disease in large parts of Asia, Africa, and Latin and South America experienced difficulty in accessing their medication, which is likely to have led to deterioration of symptom control. The email survey of the Movement Disorders Society, […]

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Predictive models could provide more accurate detection of early-stage Parkinson’s disease

How is your sense of smell? Do you find yourself frequently dozing off during the day or thrashing about during dreams? Often, early stage Parkinson’s disease does not present with typical motor disturbance symptoms, making diagnosis problematic. Now, neuroscientists at York University have found five different models that use these types of non-motor clinical as well as biological variables to […]

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Parkinson’s disease may start in the gut

Researchers at Karolinska Institutet in Sweden and the University of North Carolina in the USA have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders. One interesting finding was that cells from the gut’s nervous system are […]

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Researcher’s technology differentiates between Parkinson’s disease and multiple system atrophy

Scientists have found a way to distinguish between two progressive neurodegenerative diseases, Parkinson’s disease (PD) and multiple system atrophy (MSA), using a technology developed by a researcher at The University of Texas Health Science Center at Houston (UTHealth). The discovery was published today in Nature. It is challenging to distinguish between the two diseases because the early signs are similar—disturbances […]

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Molecular bodyguards against Parkinson’s disease

Chaperone proteins in human cells dynamically interact with the protein α-Synuclein, which is strongly associated with Parkinson’s disease. A disturbed relationship to these “bodyguards” leads to cell damage and the formation of Lewy bodies typical for Parkinson’s disease. The findings by researchers from the University of Basel’s Biozentrum have been published in Nature. Parkinson’s disease is one of the most […]

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