Predictive models could provide more accurate detection of early-stage Parkinson’s disease

How is your sense of smell? Do you find yourself frequently dozing off during the day or thrashing about during dreams? Often, early stage Parkinson’s disease does not present with typical motor disturbance symptoms, making diagnosis problematic. Now, neuroscientists at York University have found five different models that use these types of non-motor clinical as well as biological variables to […]

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Parkinson’s disease may start in the gut

Researchers at Karolinska Institutet in Sweden and the University of North Carolina in the USA have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders. One interesting finding was that cells from the gut’s nervous system are […]

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Researcher’s technology differentiates between Parkinson’s disease and multiple system atrophy

Scientists have found a way to distinguish between two progressive neurodegenerative diseases, Parkinson’s disease (PD) and multiple system atrophy (MSA), using a technology developed by a researcher at The University of Texas Health Science Center at Houston (UTHealth). The discovery was published today in Nature. It is challenging to distinguish between the two diseases because the early signs are similar—disturbances […]

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Molecular bodyguards against Parkinson’s disease

Chaperone proteins in human cells dynamically interact with the protein α-Synuclein, which is strongly associated with Parkinson’s disease. A disturbed relationship to these “bodyguards” leads to cell damage and the formation of Lewy bodies typical for Parkinson’s disease. The findings by researchers from the University of Basel’s Biozentrum have been published in Nature. Parkinson’s disease is one of the most […]

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The pathway to Parkinson’s takes a surprising twist

In neurodegenerative conditions like Parkinson’s disease, a specific group of neurons start to die one by one, causing movement problems and other symptoms. Scientists have long focused on finding out why these neurons die. Now it turns out, they might not even be dead. Researchers at The Rockefeller University found that affected neurons in Parkinson’s disease can shut down without […]

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Researchers report new insights into Parkinson’s disease-related mortality

By following a group of newly diagnosed patients with Parkinson’s disease (PD) for a decade or more, researchers have been able to identify several factors never before reported that appear to be associated with higher mortality rates in PD patients compared to the general population. As reported in the Journal of Parkinson’s Disease, these factors are early onset of PD, […]

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Exercising at home has a positive effect on Parkinson’s patients

In a large double-blind study, Radboud university medical center researchers show that patients in the early stages of Parkinson’s disease can exercise regularly at home for 6 months. This regular exercise has a positive effect on their motor disability comparable to the effect of conventional Parkinson’s medication. Even though exercise is known to be healthy, many people find it difficult […]

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New guideline on Parkinson’s disease aimed at physicians and people with Parkinson’s

A comprehensive new Canadian guideline provides practical guidance for physicians, allied health professionals, patients and families on managing Parkinson disease, based on the latest evidence. The guideline is published in CMAJ (Canadian Medical Association Journal), accompanied by an easy-to-reference infographic and podcast. Parkinson disease is a debilitating, progressive neurological condition that affects quality of life for patients and their caregivers. […]

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Parkinson’s disease: These mouth difficulties could mean you are at risk

Parkinson’s develops when cells in the brain stop working properly and are lost over time. These brain cells produce a chemical called dopamine. Symptoms start to appear when the brain can’t make enough dopamine to control movement properly. People with Parkinson’s disease commonly experience tremor (shaking), slowness of movement and rigidity (muscle stiffness) – but there are many other symptoms […]

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