Researchers identify novel approach to repair the human heart

A team of scientists from Loyola University Chicago’s Stritch School of Medicine have discovered a critical component for renewing the heart’s molecular motor, which breaks down in heart failure. Approximately 6.2 million Americans have heart failure, an often fatal condition characterized by the heart’s inability to pump enough blood and oxygen throughout the body. This discovery could represent a novel […]

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The novel coronavirus’ spike protein plays additional key role in illness

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating […]

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The novel coronavirus’ spike protein plays additional key role in illness

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating […]

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Researchers discover a novel cell-to-cell communication network that helps tumors regrow following treatment

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations—oncogenic RAS or RASV12—is also responsible for the regrowth of cancer cells following genotoxic therapy treatment, or drugs that cause damage to […]

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Novel pooled testing strategies can significantly better identify COVID-19 infections

A new approach to pooled COVID-19 testing can be a highly effective tool for curbing the SARS-CoV-2 pandemic, even if infections are widespread in a community, according to researchers at Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard. Simple pooled testing schemes could be implemented with minimal changes to current testing infrastructures in […]

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Novel principle for cancer treatment shows promising effect

Researchers at Karolinska Institutet in Sweden report in the journal Nature that they have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumor growth in mice without significantly affecting healthy cells. “We are excited to have shown that this novel principle for cancer treatment works in […]

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Novel therapy approach for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine. The novel approach utilizes receptor-targeted photodynamic therapy with exendin-4-IRDye700DX to induce phototoxicity in insulin-producing cells that cause hyperinsulinemic hypoglycemia. Insulin production by pancreatic beta cells is […]

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Novel digital dashboard improves cancer case review efficiency

Multidisciplinary tumor boards are vital to cancer treatment plans, bringing together clinicians from different specialties to guide patient treatment and improve outcomes. However, compiling the relevant data for each case is time-consuming and requires contributions from multiple team members. To optimize the process, researchers at the MU School of Medicine partnered with Roche Diagnostics to evaluate a cloud-based product called […]

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Scientists establish novel ‘Kuma mutant’ mouse model of permanent neonatal diabetes

Diabetes seldom occurs in newborns—a condition known as neonatal diabetes. But when it does, it’s mostly due to a mutation in a single gene such as the KCNJ11 or insulin (INS). This early-onset type of diabetes differs from type-1 diabetes in that it occurs within the first six months of life and can be either transient or permanent. Most of […]

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Novel targeted drug induced positive response for VHL-associated kidney cancer

In an international trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with MK-6482, the small molecule inhibitor of hypoxia-inducible factor (HIF)-2a was well tolerated and resulted in clinical responses for patients with von Hippel-Lindau disease (VHL)-associated renal cell carcinoma (RCC). The results of the Phase II trial were shared today in an oral presentation […]

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