Novel drug liberates tumor vessels to aid cancer drug delivery

A therapeutic antibody developed by scientists at UCL has been shown to unblock and normalize blood vessels inside cancerous tumors, enabling the more effective delivery of targeted cancer treatments. The findings in mice, published in the journal Med, are the first to demonstrate that inhibiting the activity of LRG1, a protein produced in many tumorous tissues, liberates disorganized angiogenesis (blood […]

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Novel checkpoint molecule of natural killer cell anti-tumor immunity revealed

Currently, immunotherapy is revolutionizing tumor therapy. However, most patients can’t benefit from available immunotherapy strategies due to limited efficacy and safety, especially those with solid tumors. Natural killer cells (NK cells) are cytotoxic innate immune cells that play an important role in immune surveillance against tumors. However, the underlying mechanisms are still poorly understood. Dr. Tian Zhigang’s group from the […]

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Novel discovery describes the mechanisms of wound detection in the body

A new study from Vanderbilt University researchers has established a novel way to understand how the body discovers and responds to wounds. The research was led by graduate student James O’Connor and Professor Andrea Page-McCaw in the Department of Cell and Developmental Biology, and Shane Hutson, chair of the Department of Physics and Astronomy and professor of physics and biological […]

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Novel imaging agent identifies biomarker for iron-targeted cancer therapies

A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration in tumors, which can help predict whether a not the cancer will respond to treatment. This research was published in the July issue of the Journal […]

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Novel study of high-potency cannabis shows some memory effects

Even before the pandemic made Zoom ubiquitous, Washington State University researchers were using the video conferencing app to research a type of cannabis that is understudied: the kind people actually use. For the study, published in Scientific Reports, researchers observed cannabis users over Zoom as they smoked high-potency cannabis flower or vaped concentrates they purchased themselves from cannabis dispensaries in […]

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Researchers identify novel approach to repair the human heart

A team of scientists from Loyola University Chicago’s Stritch School of Medicine have discovered a critical component for renewing the heart’s molecular motor, which breaks down in heart failure. Approximately 6.2 million Americans have heart failure, an often fatal condition characterized by the heart’s inability to pump enough blood and oxygen throughout the body. This discovery could represent a novel […]

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The novel coronavirus’ spike protein plays additional key role in illness

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating […]

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The novel coronavirus’ spike protein plays additional key role in illness

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating […]

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Researchers discover a novel cell-to-cell communication network that helps tumors regrow following treatment

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations—oncogenic RAS or RASV12—is also responsible for the regrowth of cancer cells following genotoxic therapy treatment, or drugs that cause damage to […]

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Novel pooled testing strategies can significantly better identify COVID-19 infections

A new approach to pooled COVID-19 testing can be a highly effective tool for curbing the SARS-CoV-2 pandemic, even if infections are widespread in a community, according to researchers at Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard. Simple pooled testing schemes could be implemented with minimal changes to current testing infrastructures in […]

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