Playing with the ‘new normal’ of life under coronavirus

The COVID-19 pandemic has recalibrated everything: work, life and play. As work, schooling, socializing and play have moved into the digital and the confines of our homes, cities have become spaces for reimagining—especially as new sites for formal and informal play. Playgrounds—once filled with children, parents, grandparents and animals—now look like crime scenes, with police tape and all. They have […]

Read more

I Had a Perfectly Normal EKG at My Check-Up—and the Next Day I Had a Heart Attack

  On the day of my annual physical, I wasn’t worried about my heart: At 63, I was a non-smoker with a BMI of 20 who got (mostly) regular exercise and took no daily medication. A blood test the week prior had shown my total cholesterol was 187, with a good HDL/LDL ratio and low triglycerides. The report included this reassuring notation: “lower relative cardiovascular risk […]

Read more

Small populations of normal cells affect immunity in patients with XLP1

Human SH2D1A mutations resulting in X-linked lymphoproliferative syndrome type 1 (XLP1) are associated with a unique susceptibility to the Epstein-Barr virus (EBV), which may lead to fatal infectious mononucleosis (FIM). Many studies have attempted to elucidate an appropriate treatment for XLP1 that does not involve hematopoietic stem cell transplantation (HSCT); clinical evidence supporting such treatments has been minimal, until now. […]

Read more