Mapping the neurons of the rat heart in 3-D

An interdisciplinary team of researchers has developed a virtual 3-D heart, digitally showcasing the heart’s unique network of neurons for the first time. Using the rat heart as a model, the investigators in this study—appearing May 26 in the journal iScience—created a comprehensive map of the intrinsic cardiac nervous system (ICN) at a cellular scale. This map allows for gene […]

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Tweaked CRISPR in neurons gives scientists new power to probe brain diseases

A team of scientists at UC San Francisco and the National Institutes of Health have achieved another CRISPR first, one which may fundamentally alter the way scientists study brain diseases. In a paper published August 15 in the journal Neuron, the researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity […]

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Taking out the protein garbage becomes more difficult as neurons age

Cells dispose of harmful “trash” through autophagy, a normal and necessary process in which aggregated proteins and dysfunctional structures are handled. If any part of this fails, waste builds up inside cells, eventually killing them. According to a new study from the Perelman School of Medicine at the University of Pennsylvania, as cells age, their ability to shed harmful refuse […]

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Researchers discover serotonin can regulate gene expression inside neurons

The brain chemical serotonin, a neurotransmitter long known for its role in passing signals between neurons in the brain, can also regulate expression of genes within neurons in an unexpected way, according to research conducted by neuroscientists at the Icahn School of Medicine at Mount Sinai and published on March 13 in the journal Nature. The discovery may help scientists […]

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Combination of alcohol and Smoking can cause neural damage to the brain

Alcohol and Smoking are a very dangerous combination Tobacco Smoking causes, among many other health consequences of chemical changes, oxidative Stress and inflammation in the brain. Excessive alcohol consumption can have similar effects. The common use of tobacco and alcohol seems to even result in neural damage in certain regions of the brain. The scientists from the Universidade Federal do […]

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Identity crisis of satiety neurons leads to obesity

Obesity − as research in the past decade has shown − is first and foremost a brain disease. Researchers at Helmholtz Zentrum München, partners in the German Center for Diabetes Research, have now discovered a molecular switch that controls the function of satiety neurons and therefore body weight. The findings were published in the journal Nature Metabolism. The worldwide epidemic […]

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