Novel checkpoint molecule of natural killer cell anti-tumor immunity revealed

Currently, immunotherapy is revolutionizing tumor therapy. However, most patients can’t benefit from available immunotherapy strategies due to limited efficacy and safety, especially those with solid tumors. Natural killer cells (NK cells) are cytotoxic innate immune cells that play an important role in immune surveillance against tumors. However, the underlying mechanisms are still poorly understood. Dr. Tian Zhigang’s group from the […]

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Researchers discover molecule that provides dual protection against vascular inflammation

A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity. The study, published in the journal Nature Communications, revealed how one gene encoded two molecules that provide two-pronged protection following […]

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Curcumin nanosystems could be powerful COVID-19 therapeutics

With new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging, the coronavirus disease 2019 (COVID-19) pandemic is far from over. While the global vaccine rollout has moved at an impressive speed, the search for new safe, effective, and targeted therapies is still on. Now, a new study in Biomedicine and Pharmacotherapy reviews the potential for curcumin, a natural […]

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New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

With the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it came to light that there were no specific and highly effective preventive or therapeutic agents against this virus. The result has been an enormous amount of studies reporting the efficacy or otherwise of novel drug candidates or repurposed drugs […]

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Manufacturers of fragrance products are using new way to source ingredients

In the face of a changing climate and crop diseases, manufacturers of products containing natural flavors and fragrances are pivoting to a new way to source ingredients. Companies have been partnering with biotechnology firms to manufacture scents and flavors using fermented microbes, which experts say are more sustainable. A new story in Chemical & Engineering News (C&EN), the weekly newsmagazine […]

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Super-Resolution Microscopy vs. Electron Microscopy

Skip to: Super-Resolution Microscopy Electron Microscopy Disadvantages of Electron Microscopy SRM vs. EM: Two Powerful Tools for the Researcher Conventional light microscopy has its limits. Light, being a wave, is subject to diffraction which severely limits the size of structures one can resolve. To be able to observe parts of an organism smaller than this, other techniques need to be […]

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Promising molecule targets protein to offer hope for people with Parkinson’s

Results from a study published today looking at a molecule targeting clumps of alpha-synuclein, a key protein linked to Parkinson’s, offers hope that it may be possible to slow down or prevent the progression of the condition in humans. Researchers at the University of Cambridge have been able to investigate the effect of a molecule called anle138b, by developing a […]

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