Molecular bodyguards against Parkinson’s disease

Chaperone proteins in human cells dynamically interact with the protein α-Synuclein, which is strongly associated with Parkinson’s disease. A disturbed relationship to these “bodyguards” leads to cell damage and the formation of Lewy bodies typical for Parkinson’s disease. The findings by researchers from the University of Basel’s Biozentrum have been published in Nature. Parkinson’s disease is one of the most […]

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Researchers identify a molecular mechanism involved in Huntington’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona (UBNeuro) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington’s disease, a genetic neurodegenerative disease. These results, published in the journal Brain, could help […]

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New pulsed electric field technology could lead to less invasive tumor molecular profiling

Current cancer treatment courses often begin with tissue biopsies. Biopsies, however, which involve the physical resection of a small tissue sample, can lead to localized tissue injury, bleeding, inflammation, and stress, as well as increased risk of metastasis. New technology developed by a team of researchers from Tel Aviv University (TAU), Herzliya Interdisciplinary (IDC), and Technion-Israel Institute of Technology may […]

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Molecular control of neurotransmitter linked to autism described

Many neurodevelopmental disorders such as epilepsy, schizophrenia, and autism have been linked to disruption of the key neurotransmitter GABA, but the underlying causes of the disruptions have been difficult to pinpoint. In two new papers published Oct. 15 in Science Signaling, researchers from Yale, France, Japan, and the United Kingdom have zeroed in on a molecular mechanism crucial to normal […]

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Molecular link between chronic pain and depression revealed

Researchers at Hokkaido University have identified the brain mechanism linking chronic pain and depression in rats. Their research, which was recently published in the Journal of Neuroscience, could lead to the development of new treatments for chronic pain and depression. “Clinicians have known for a long time that chronic pain often leads to depression, however the brain mechanism for this […]

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