Predictive models could provide more accurate detection of early-stage Parkinson’s disease

How is your sense of smell? Do you find yourself frequently dozing off during the day or thrashing about during dreams? Often, early stage Parkinson’s disease does not present with typical motor disturbance symptoms, making diagnosis problematic. Now, neuroscientists at York University have found five different models that use these types of non-motor clinical as well as biological variables to […]

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Worm extract found to reduce inflammation in mouse models

A team of researchers from Germany, Switzerland, Sweden and Australia has found that a substance isolated from roundworm larvae was able to reduce inflammation in the airways of mice. In their paper published in the journal Science Translational Medicine, the group describes extracting a protein from a type of parasite that infects rodents and used it to make a nasal […]

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Scientists eager to explain brain rhythm boost’s broad impact in Alzheimer’s models

The sweeping extent to which increasing 40Hz “gamma” rhythm power in the brain can affect the pathology and symptoms of Alzheimer’s disease in mouse models has been surprising, even to the MIT neuroscientists who’ve pioneered the idea. So surprising, in fact, they can’t yet explain why it happens. In three papers, including two this year in Cell and Neuron, they’ve […]

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Drug combination shows promise in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone. Hollings Cancer Center scientists at the Medical University of South Carolina reported these findings in PLOS ONE. TNBC disproportionately affects African […]

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Proposed gene therapy for a heart arrhythmia, based on models made from patient cells

Researchers at Boston Children’s Hospital report creating the first human tissue model of an inherited heart arrhythmia, replicating two patients’ abnormal heart rhythms in a dish, and then suppressing the arrhythmia with gene therapy in a mouse model. Their work, published in two papers in the July 30 print issue of the journal Circulation, opens the possibility of developing single-dose […]

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Study reveals lower predictive ability for renal cancer models

(HealthDay)—Prospective validation of existing renal cell carcinoma (RCC) prediction models demonstrates a decrease in their predictive ability, according to a study published online June 19 in the Journal of Clinical Oncology. Andres F. Correa, M.D., from the Fox Chase Cancer Center in Philadelphia, and colleagues validated eight RCC recurrence models and the Tumor, Node, Metastasis (TNM) staging system using data […]

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Model Belle Lucia Says Bullies Who Criticize Her 6-Month Pregnancy Bump Have a ‘Sad Life’

Model Belle Lucia wants the people who spend time on Instagram criticizing the size of her baby bump to find a new activity. The mom-to-be, who has spent much of her six months of pregnancy defending herself from critics who say her bump is too small, called them out in her Instagram story on Tuesday. “If you’re spending your time […]

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5 ‘SI Swimsuit’ Models Spill Their Diets: Dairy Out, Tequila In

It’s the job of Sports Illustrated Swimsuit models to look good in bikinis. And while the 2019 models follow some of the same diet and fitness tips as each other to get beach-ready, they also have differences. Beach beauties Jasmine Sanders, Danielle Herrington, Barbara Palvin, Olivia Culpo and Kelsey Merritt stopped by the Us Weekly studios to debate the best […]

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