Researchers discover how tumor-killing immune cells attack lymphomas in living mice

In a study that will be published April 1 in the Journal of Experimental Medicine, researchers from the Institut Pasteur and INSERM reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these immune cells work and how their effectiveness could be improved in the treatment […]

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New microscope captures large groups of neurons in living animals: Fast, detailed imaging across a wide field of view useful for deciphering brain functions

Researchers have developed a microscope specifically for imaging large groups of interacting cells in their natural environments. The instrument provides scientists with a new tool for imaging neurons in living animals and could provide an unprecedented view into how large networks of neurons interact during various behaviors. In Optica, The Optical Society’s journal for high-impact research, researchers from Boston University, […]

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Sex and aggression in mice controlled by cold-sensor in brain

Testosterone is blamed for sex drive and aggression, but it also appears to be critical for telling the brain “enough!” when it comes to those behaviors. A molecule called TRPM8 (pronounced trip-M-8) embedded in the surface of some cells seems to be responsible for sending these cues in response to testosterone. Without these cues, male mice become dangerously aggressive and […]

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Dementia patients’ memories could be RESTORED, study on mice suggests

Dementia patients’ memories could be RESTORED with injection to suppress certain enzymes, study on mice suggests University of Buffalo scientists injecting dementia-stricken rodents with a new drug They saw a ‘dramatic’ shift in the rodents’ recognition memory, spatial memory and working memory Mice with dementia had their memories restored after receiving an injection to suppress a certain enzyme, a new […]

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Teen brain volume changes with small amount of cannabis use, study finds

At a time when several states are moving to legalize recreational use of marijuana, new research shows that concerns about the drug’s impact on teens may be warranted. The study, published in The Journal of Neuroscience, shows that even a small amount of cannabis use by teenagers is linked to differences in their brains. Senior author and University of Vermont […]

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Can We Really Inherit Trauma?

In mid-October, researchers in California published a study of Civil War prisoners that came to a remarkable conclusion. Male children of abused war prisoners were about 10 percent more likely to die than their peers were in any given year after middle age, the study reported. The findings, the authors concluded, supported an “epigenetic explanation.” The idea is that trauma […]

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A bacterial protein is found to promote cancer: Research suggests suggests that bacterial infections may contribute to far more cancers than previously thought

The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) announced today the discovery that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell’s ability to respond to and repair DNA damage, a known origin of cancer. Little or no mycoplasma DnaK DNA sequences were found associated with the tumor, which was […]

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Great apes and ravens plan without thinking

Planning and self control in animals do not require human-like mental capacities, according to a study from Stockholm University. Newly developed learning models, similar to models within artificial intelligence research, show how planning in ravens and great apes can develop through prior experiences without any need of thinking. Researchers have previously suggested that ravens can plan better than four-year-old children. […]

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Microglia react distinctively during inflammation: LIH scientists provide new insights into function and heterogeneity of brain immune cells

The NorLux Neuro-Oncology Laboratory at LIH’s Department of Oncology conducts research on brain diseases, with a special emphasis on glioma biology, drug resistance and systems approaches. Within this research unit, Dr. Alessandro Michelucci focuses on the role of glial cells and inflammatory responses. Jointly with team member Dr. Carole Sousa and collaborating research groups from LIH and the University of […]

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Drug combination makes cancer disappear in mice with neuroblastoma

Researchers investigating new treatments for neuroblastoma—one of the most common childhood cancers—have found that a combination of two drugs made tumours disappear in mice, making it more effective than any other drugs tested in these animals. Professor Murray Norris, deputy director of the Children’s Cancer Institute Australia for Medical Research, Sydney, Australia, told the 30th EORTC-NCI-AACR Symposium on Molecular Targets […]

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