Research in mice shows how diet alters immune system function through a gut microbe

The cliché “you are what you eat” has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.  The work, conducted in mice, reveals that what animals consume initiates the release of […]

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Not-so-blind mice can make strategic and acute visual choices

New research from the RIKEN Center for Brain Science shows that mice can teach us about decision-making strategies. Mice in the study autonomously trained themselves to make decisions about detailed pictures on a screen. A dataset of over 1.3 million viewings of black and white striped lines revealed that mice were highly sensitive to small differences in how slanted the […]

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Mice treated with this cytokine lose weight by ‘sweating’ fat

Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly, the fat loss was not associated with decreased food intake or faster metabolism. Instead, the researchers discovered that […]

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A new technology to see tubes in 3-D in mice shows how the liver can recover in Alagille syndrome

Many diseases affect different vessels in our body, such as blood vessels, bile ducts or airways. Visualizing these in animal models of disease, to better understand what is actually going wrong form a structural point of view has been an area of intense research. We developed a new method, independent of antibodies or microscopes, to visualize multiple vessels at the […]

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Scientists discover how COVID-19 virus causes multiple organ failure in mice

UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs. “This mouse model is a really powerful tool for studying SARS-CoV-2 […]

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Delivering immune-stimulating nanoparticles to the lungs via red blood cells halts metastatic tumor growth in mice

When a patient with cancer is told the devastating news that their disease has spread, or metastasized, to a new part of their body, it has most often moved to their lungs. The branching blood vessels that allow oxygen to diffuse from the lungs’ air sacs into red blood cells are so tiny that a rogue cancer cell circulating in […]

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Scientists show jet lag conditions impair immune response in mice

Imagine you’ve just arrived in Paris. Your body thinks it should be midnight—a restorative time when your cells typically proofread DNA, organize and store energy, and perform other essential chores—but, instead, the sun is up and you’re awake. On a molecular level, your cells are stressed, trying to catch up to new environmental conditions. Shiftwork and experimental models of frequent […]

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Adult stem cells/glaucoma drug combo promotes diabetic wound healing in mice

A new study released today in Stem Cells Translational Medicine shows promise of a major breakthrough in healing chronic foot ulcers resulting from diabetes. The study, by researchers at the University of California, Davis, is the first to demonstrate how a bioengineered scaffold made up of human mesenchymal stem cells (MSCs) combined with timolol—a drug commonly used to treat glaucoma—improved […]

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