Adult stem cells/glaucoma drug combo promotes diabetic wound healing in mice

A new study released today in Stem Cells Translational Medicine shows promise of a major breakthrough in healing chronic foot ulcers resulting from diabetes. The study, by researchers at the University of California, Davis, is the first to demonstrate how a bioengineered scaffold made up of human mesenchymal stem cells (MSCs) combined with timolol—a drug commonly used to treat glaucoma—improved […]

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Experimental drug reduces replication of zika virus and prevents microcephaly in mice

An international group of researchers have discovered that inhibiting AHR (aryl hydrocarbon receptor)—a protein with roles in regulating immunity, stem cell maintenance and cellular differentiation—enables the immune system to combat replication of zika virus in the organism far more effectively. In experiments performed at the University of São Paulo’s Biomedical Sciences Institute (ICB-USP) in Brazil, the antiviral therapy proved capable […]

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Sodium found to regulate the biological clock of mice

A new study from McGill University shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long distance travel or shift work. The findings, published in Nature by former McGill Ph.D. student Claire Gizowski and Charles Bourque, a professor […]

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Mice ‘detectives’ hint at how humans read between the lines

Some people are annoyingly good at “reading between the lines.” They seem to know, well before anyone else, who is the killer in a movie, or the meaning of an abstract poem. What these people are endowed with is a strong inference capability—using indirect evidence to figure out hidden information. But inference is not a skill possessed by the lucky […]

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Blue light triggers memory and emphatic fear in mice via noninvasive approach

Researchers at the Center for Cognition and Sociality, within the Institute for Basic Science (IBS) in South Korea, have engineered an improved biological tool that controls calcium (Ca2+) levels in the brain via blue light. Published in Nature Communications, this optogenetic construct, called monster-OptoSTIM1 or monSTIM1 for short, causes a change in mice’s fear learning behavior without the need of […]

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Cannabinoids improve symptoms in mice with endometriosis

Initial results from treating endometriosis in mice with cannabinoids suggest they can alleviate some symptoms of the disease, according to a new study in the open-access journal eLife. The findings have led to the start of a clinical trial in collaboration with the Gynecology Service of the Hospital Clinic of Barcelona, Spain. This trial will evaluate the possible benefits of […]

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Alzheimer’s amyloid build-up affects certain parts of brain cells more than others in mice

A protein that is linked with Alzheimer’s Disease has been found to be more likely to affect certain parts of brain cells that send messages than other parts of the cells. In a new study published in Scientific Reports, the team observed how amyloid beta (Aβ), a protein which accumulates in the brain of people with Alzheimer’s disease, affected the […]

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Diet impacts the sensitivity of gut microbiome to antibiotics, mouse study finds

Antibiotics save countless lives each year from harmful bacterial infections — but the community of beneficial bacteria that live in human intestines, known as the microbiome, frequently suffers collateral damage. Peter Belenky, an assistant professor of molecular microbiology and immunology at Brown University, studies ways to minimize this side effect, which can lead to C. diff infections and other life-threatening […]

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Deadly tick-borne virus cured with experimental flu drug, in mice: Bourbon virus has sickened people in Kansas, Missouri, Oklahoma

Only a few cases of the newly discovered Bourbon virus have been reported, and two of them ended in death, partly because no specific treatments are available for the tick-borne illness. Now, researchers at Washington University School of Medicine in St. Louis have identified an experimental antiviral drug that cures mice infected with the potentially lethal virus. The drug, favipiravir, […]

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On the way to fighting staph infections with the body’s immune system

Researchers have gained a greater understanding of the biology of staphylococcus skin infections in mice and how the mouse immune system mobilizes to fight them. A study appears this week in the Proceedings of the National Academy of Sciences. Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) typically causes skin infections but can spread throughout the body to cause invasive infections such […]

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