Faulty brain circuits repaired using nanotechnology: Possible new drug targets for dementia and intellectual disability

Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories. Using mice genetically engineered and bred with […]

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Alzheimer’s disease is a ‘double-prion disorder’: Self-propagating amyloid and tau prions found in post-mortem brain samples, with highest levels in patients who died young

Two proteins central to the pathology of Alzheimer’s disease act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — according to new UC San Francisco research. Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of the proteins amyloid […]

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New target for chronic pain: Shape of structure that nerve cells use to sense cold

People are great at detecting cold temperatures and also the cool sensation induced by natural substances like menthol, which is common in remedies used to soothe aching muscles. But it hasn’t been entirely clear how we do this. About a year ago, a group of researchers led by Seok-Yong Lee, Associate Professor of Biochemistry in the Duke University School of […]

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