Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University (Japan) have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure […]

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What is a Cytoskeleton?

The cytoskeleton of a cell helps provide shape, strength, and an organised structure to the cell. The cytoskeleton can be compared to a transport network facilitating various types of movement in the cell. It helps with cell reproduction, the movement of organelles, the functions of muscles and intracellular transport between the organelles. It also enables the separation of daughter chromosomes […]

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Crystal Structure of the Human Cannabinoid Receptor CB2

Skip to: Making Crystals of the Antagonist The Structure Interaction of the Antagonist with CB2 Activation of CB2 Phytocannabinoids in the form of Cannabis plant is widely consumed by humans. Two of the cannabinoid receptors, CB1 and CB2 are the key targets of this endocannabinoid system. While CB1 is widely present across the body, CB2 is mainly present in the […]

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