Study reveals cancer immunotherapy patients at most risk of life-threatening side effects

Many patients with cancer receive immune checkpoint inhibitors that strengthen their immune response against tumor cells. While the medications can be life-saving, they can also cause potentially life-threatening side effects in internal organs. This double-edged sword makes it challenging for clinicians to decide who should be considered candidates for treatment. A new analysis led by researchers at Massachusetts General Hospital […]

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A collaborative effort to evaluate treatment of liver and pancreatic tumors

HOUSTON, DENVER and CHICAGO ? The University of Texas MD Anderson Cancer Center and TriSalus Life Sciences today announced a strategic research collaboration to evaluate the treatment of tumors of the pancreas and liver by integrating interventional delivery of SD-101, an investigational toll-like receptor 9 (TLR9) agonist, in combination with checkpoint inhibition immunotherapy. Under the agreement, MD Anderson and TriSalus […]

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Newly identified biomarker could predict response to immune checkpoint inhibitors

A team of Roswell Park Comprehensive Cancer Center researchers has identified a new biomarker that could predict response to immune checkpoint inhibitors (ICI) shortly after patients with non-small cell lung cancer (NSCLC) initiate therapy. This discovery, published today in the journal Nature Communications, is not only an important step forward in lung cancer treatment, but also has implications for other […]

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New analysis method for predicting the risks and effects of immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment. Immunotherapy—using the body’s own immune […]

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Fighting breast cancer with nanotech, immunotherapy

A team of scientists led by a researcher at the Case Western Reserve University School of Medicine is making strides to fight deadly metastatic breast cancer by combining nanotechnology with immunotherapy. Efstathios “Stathis” Karathanasis, an associate professor of biomedical engineering, is directing the novel technique—sending nanoparticles into the body to wake up “cold” tumors so they can be located and […]

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‘Deep dive’ into biology of kidney tumors identifies markers of response to immunotherapy

Treatments for kidney cancer have improved considerably over the past few decades. In 1988, when Memorial Sloan Kettering oncologist Robert Motzer started researching the disease, the average survival was less than one year. There were no approved therapies at the time besides surgery. By 2005, with the development of targeted drugs such as sunitinib (Sutent), survival nearly tripled. Today, with […]

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A machine learning-based algorithm to predict which cancer patients benefit from immunotherapy

Scientists at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with the Centre for Genomic Regulation (CRG) and Radboud University, have developed an algorithm that can predict which cancer patients are more likely to benefit from immunotherapy. Mutations in our DNA can disrupt protein synthesis, sometimes causing truncated proteins which don’t work as intended. Known as nonsense mutations, […]

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Immunotherapy drug could help women with aggressive breast cancer

Immunotherapy drug could halt the return of the ‘most aggressive form of breast cancer’ and ‘save thousands of lives’ Women with triple negative breast cancer were given the drug Keytruda  Keytruda was taken alongside chemo to shrink tumours before surgery More than 60% of the patients showed no sign of cancer after the operation An immunotherapy drug could prevent a […]

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CAR T cell therapy: On the cusp of ‘an immunotherapy revolution’?

A deeper understanding of the immune system’s role in controlling cancer has helped drive “an immunotherapy revolution,” offering hope for many patients with previously incurable cancers, including children, doctors have concluded in a new report. The assessment, from two Stanford University doctors, is part of their broader analysis on lessons learned from “the first leg of the CAR T cell […]

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