Immune system protein may defend against deadly intestinal disease in babies

The intestinal disease necrotizing enterocolitis is a leading cause of death among premature infants born in the U.S. and across the globe. Characterized by excessive inflammation that can cause tissue decay in the bowels, the disease provides a pathway for infectious and deadly bacteria to enter the bloodstream. Despite four decades of research, effective treatments remain elusive, and mortality rates […]

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Scientists discover immune cell behavior that plays a key role in Alzheimer’s disease

A new study has pinpointed a small group of cells in the brain which could be crucial to understanding how Alzheimer’s disease begins and how to slow its progression. This discovery could help research into treatment for the disease by focusing on this key group of cells in the brain. Alzheimer’s disease is the most common type of dementia, affecting […]

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No, vaccine side effects don’t tell you how well your immune system will protect you from COVID-19

If someone gets a headache or feels a bit under the weather after receiving a COVID-19 vaccine, it’s become common to hear them say something like “Oh, it just means my immune system is really working hard.” On the flip side, when people don’t notice any side effects, they sometimes worry the shot isn’t doing its job or their immune […]

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Researchers identify immune cells that contribute to transplant rejection

Non-circulating memory T cells, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection, University of Pittsburgh School of Medicine researchers reveal in a paper published today in Science Immunology. The scientists show that these “tissue-resident memory T cells” are harmful in situations where antigens that the cells recognize are present in the body for […]

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Researchers reveal mechanism of hepatitis B-induced venous metastasis and immune escape of hepatocellular carcinoma

In China, about 70 million people are infected with hepatitis B virus (HBV), and more than 80% of liver cancer is caused by HBV. HBV-associated hepatocellular carcinoma (HCC) is often accompanied by severe vascular invasion and portal vein tumor thrombus leading to a poor prognosis. However, the underlying mechanism of this disease remains obscure. In a study published in Cancer […]

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Immune cell implicated in development of lung disease following viral infection

Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection. The evidence suggests that activation of this immune cell—a type of guardian cell called a dendritic cell—serves as an early switch that, when activated, sets in motion […]

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Mapping an effective immune response to COVID-19

Melbourne researchers have systematically mapped the immune response to COVID-19 identifying how antibodies develop in response to SARS-CoV2 and new insights into why some people develop severe disease. The team, led by University of Melbourne Professor Katherine Kedzierska, a laboratory head at the Peter Doherty Institute for Infection and Immunity (Doherty Institute), identified that multiple arms of the immune system […]

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Human immune cells have natural alarm system against HIV

Treatment for HIV has improved tremendously over the past 30 years; once a death sentence, the disease is now a manageable lifelong condition in many parts of the world. Life expectancy is about the same as that of individuals without HIV, though patients must adhere to a strict regimen of daily antiretroviral therapy, or the virus will come out of […]

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