Scientists identify new therapeutic target in ovarian cancer subtype with poor prognosis

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online […]

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Researchers identify novel approach to repair the human heart

A team of scientists from Loyola University Chicago’s Stritch School of Medicine have discovered a critical component for renewing the heart’s molecular motor, which breaks down in heart failure. Approximately 6.2 million Americans have heart failure, an often fatal condition characterized by the heart’s inability to pump enough blood and oxygen throughout the body. This discovery could represent a novel […]

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Researchers identify immune cells that contribute to transplant rejection

Non-circulating memory T cells, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection, University of Pittsburgh School of Medicine researchers reveal in a paper published today in Science Immunology. The scientists show that these “tissue-resident memory T cells” are harmful in situations where antigens that the cells recognize are present in the body for […]

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Scientists identify genetic pathway that suppresses Lou Gehrig’s Disease

Professor Chunghun Lim and his research team in the Department of Biological Sciences unveiled a neuroprotective pathway that suppresses Lou Gehrig’s Disease (ALS). Nucleocytoplasmic transport (NCT) defects have been implicated in neurodegenerative diseases, such as C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). In this study, the research team has identified a neuroprotective pathway of like-Sm protein 12 (LSM12) and […]

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Novel pooled testing strategies can significantly better identify COVID-19 infections

A new approach to pooled COVID-19 testing can be a highly effective tool for curbing the SARS-CoV-2 pandemic, even if infections are widespread in a community, according to researchers at Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard. Simple pooled testing schemes could be implemented with minimal changes to current testing infrastructures in […]

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Researchers identify four causes of "Zoom fatigue" and their simple fixes

Even as more people are logging onto popular video chat platforms to connect with colleagues, family and friends during the COVID-19 pandemic, Stanford researchers have a warning for you: Those video calls are likely tiring you out. Prompted by the recent boom in videoconferencing, communication Professor Jeremy Bailenson, founding director of the Stanford Virtual Human Interaction Lab (VHIL), examined the […]

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Researchers identify muscle factor that controls fat metabolism

Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body’s glucose levels, which is important for the development of metabolic diseases like diabetes. In a recent study, published in The Journal of Clinical Investigation, […]

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The next vaccine breakthrough: Health experts identify ways to help people trust a coronavirus vaccine

The pharmaceutical companies Pfizer and BioNtech announced Nov. 20, 2020, that they will seek emergency use authorization from the Food and Drug Administration for a vaccine to prevent COVID-19. On Nov. 16, Moderna announced that a vaccine it has been working on has been shown to be close to 95% effective. But no vaccine will be anywhere nearly that effective […]

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Researchers identify the mechanism behind bone marrow failure in Fanconi anaemia

Fanconi anemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer. The molecular mechanisms behind FA are inherited mutations in genes encoding for DNA repair proteins, leading to irreversible bone marrow failure. The exact mechanisms how these genetic mutations lead to the exhaustion of stem cells from the […]

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Q&A: How parents can identify anxiety warning signs as students return to school

When students across British Columbia head back to school, they’ll enter a new world of COVID-19 precautions and protocols. Consequently, students of all ages, from kindergarten to Grade 12, may experience higher levels of anxiety with varying symptoms and consequences. Steven Taylor, professor at UBC’s department of psychiatry, a clinical psychologist, and author of “The Psychology of Pandemics” has some […]

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