‘First complete models’ of a human embryo made in the lab

Scientists have created hollow spheres of cells that resemble human embryos in their earliest stages of development. The artificial embryos, called “blastoids,” could allow scientists to study early human development, infertility and pregnancy loss without experimenting on actual embryos.     Two separate research groups created these model embryos using different methods, and each published their results March 17 in the […]

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Sanofi to start human trials of its second COVID vaccine candidate

French pharmaceutical firm Sanofi on Friday announced the launch of human trials of its second COVID-19 vaccine, with its first still in the testing phase after having fallen behind in development. Sanofi and US company Translate Bio are developing the vaccine based on messenger RNA technology. The phase 1 and 2 trials aim to verify that the vaccine is not […]

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Research identifies obesity and infection link, as well as treatment found on healthy human skin

The list of diseases and conditions complicated by obesity is a long one; it includes heart disease, cancer, diabetes and impaired wound healing, as well as skin infections. It is not always clear, however, in what way this complication is caused. New research from the School of Pharmaceutical Science at Xiamen University and the Gallo Lab at UC San Diego […]

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Human immune cells have natural alarm system against HIV

Treatment for HIV has improved tremendously over the past 30 years; once a death sentence, the disease is now a manageable lifelong condition in many parts of the world. Life expectancy is about the same as that of individuals without HIV, though patients must adhere to a strict regimen of daily antiretroviral therapy, or the virus will come out of […]

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Revisiting the Global Workspace orchestrating the hierarchical organisation of the human brain

The celebrations in the 250th anniversary of the birth of Ludwig van Beethoven would not be the same without Herbert von Karajan’s brilliant performances conducting Beethoven’s memorable symphonies. The execution of any musical symphony is a hugely difficult task, demanding very significant skills on the part of each individual musician—but perhaps the most difficult task lies with the conductor who […]

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Three-dimensionally reconstituted organoids that are just like human organs

Organoids are organ-like tissues derived from stem cells that are grown in labs, often referred to as miniature organs. Because they can imitate the structure and function of human organs, they are considered a next-generation technology for creating artificial organs or developing new drugs. Recently, a research team in Korea introduced a new concept of mini-organs called assembloids that surpass […]

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A human gene placed in fruit flies reveals details about a human developmental disorder

Meier-Gorlin syndrome, or MGS, is a rare genetic developmental disorder that causes dwarfism, small ears, a small brain, missing patella and other skeletal abnormalities. In severe cases, MGS results in miscarriages and stillbirths. Igor Chesnokov, Ph.D., and his University of Alabama at Birmingham colleagues study this recessive, autosomal disorder in an unusual way—by placing mutant human genes into fruit flies. […]

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Human egg cells are imperfect surprisingly often

More than 7% of human oocytes contain at least one exchangeless chromosome pair, demonstrating a remarkably high level of meiotic recombination failure, finds a study appearing December 10 in the American Journal of Human Genetics. The findings suggest that right from the get-go of human egg cell development, a striking proportion of oocytes are predestined to be chromosomally abnormal. But […]

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Researchers create human airway stem cells from patients’ cells

For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium in response to injury, this study may help accelerate research on diseases impacting the […]

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US developing coronavirus strain for human ‘challenge’ trials

US scientists are developing a strain of the coronavirus that could be used to deliberately infect volunteers in so-called “challenge studies,” a government agency said Friday. The work is preliminary and the government is continuing to prioritize randomized clinical trials of vaccine candidates, the National Institute for Allergies and Infectious Diseases (NIAID) said. Several of these have entered their final […]

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