City or Country Life? Genetic Risk for Mental Illness May Decide

High genetic risk for a range of psychiatric illnesses appears to influence individuals’ choice of urban or rural life, new research suggests. Individuals with a genetic predisposition to schizophrenia, bipolar disorder (BD), autism spectrum disorder (ASD), or anorexia nervosa (AN) are significantly more likely to move from a rural to an urban setting, whereas those at high genetic risk for […]

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New genetic link to male infertility found

The findings published in eLife show that men with this unstable subtype of the Y chromosome have a significantly increased risk of genomic rearrangements. These rearrangements affect the sperm production process (spermatogenesis) and consequently, these men can be up to nine times more likely to have fertility issues. Molecular diagnostics of this genetic variant could help identify those at higher […]

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New genetic link to male infertility found

The findings published in eLife show that men with this unstable subtype of the Y chromosome have a significantly increased risk of genomic rearrangements. These rearrangements affect the sperm production process (spermatogenesis) and consequently, these men can be up to nine times more likely to have fertility issues. Molecular diagnostics of this genetic variant could help identify those at higher […]

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New initiatives expand COVID-19 saliva-based testing to underserved schools in Illinois

The University of Illinois System, with a $1.4 million grant from The Rockefeller Foundation, announces the expansion of its SHIELD Illinois and SHIELD CU COVID-19 testing initiatives to help safely reopen underserved K-12 schools in communities across the state using the covidSHIELD test, an innovative, saliva-based test developed at the University of Illinois Urbana-Champaign (UIUC). More than 1.5 million covidSHIELD […]

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Researchers test novel gene regulation approach to treat brain diseases

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies. It leverages zinc finger proteins, which specifically bind to the DNA that codes for the protein Tau without altering it, thereby reducing Tau production in […]

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Novel computer-guided design tool helps increase the efficiency of cell conversions

There is a great need to generate various types of cells for use in new therapies to replace tissues that are lost due to disease or injuries, or for studies outside the human body to improve our understanding of how organs and tissues function in health and disease. Many of these efforts start with human induced pluripotent stem cells (iPSCs) […]

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The origin of SARS-CoV-2 furin cleavage site remains a mystery

The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has largely defied attempts to contain its spread by non-pharmaceutical interventions (NPIs). With the massive loss of life and economic damage, the only way out, in the absence of specific antiviral therapeutics, has been the development of vaccines to achieve population immunity. […]

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A genomic barcode tracker for immune cells

Researchers from the Garvan Institute of Medical Research have developed a new method to spot rare immune cells that are reactive against cancer cells, from within a patient’s own immune system. The patented ‘RAGE-seq’ method enables scientists to track how immune cells evolve inside tumour tissue for the first time, revealing unprecedented insight into how to better arm the immune […]

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New study highlights need for ethnic and ancestral diversity in genomic research

A new multicenter analysis led by researchers at the Fred Hutchinson Cancer Research Center, the Icahn School of Medicine at Mount Sinai and other institutions found the inclusion of diverse, multiethnic populations in large-scale genomic studies is critical for reducing health disparities and accurately representing genetics-related disease risks in all populations. The results appear in the June 19 issue of […]

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