Study finds genetic markers may predict severity of COVID-19 infection

Scientists at the University of Colorado School of Medicine, along with colleagues at UCHealth University of Colorado Hospital, have discovered specific genetic biomarkers that not only show who is infected with COVID-19, but offer insights into how severe the disease might be, filling a major diagnostic gap. “I think this study is a tremendous proof-of-concept in the realm of COVID-19 […]

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I’m Haunted by Sisters With Sickle Cell: Two Thrived. Two Suffered.

Times Insider explains who we are and what we do, and delivers behind-the-scenes insights into how our journalism comes together. As a medical reporter, I regularly write about terrible illnesses and about treatments that can help some, though not most, patients. But the cruel injustice of inequities in access to medical advances in sickle cell disease took my breath away. […]

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High genetic running capacity promotes efficient metabolism with aging

High running capacity is associated with health and longevity. However, whether high genetic running capacity promotes more efficient metabolism with aging is not known. A new study conducted in collaboration between the universities of Shanghai Jiao Tong University (China) and Jyväskylä (Finland) investigated the effects of genetic running capacity and aging on tissue metabolism. The study reveals that adipose tissue […]

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Breast cancer survivors with excess body weight at increased risk of developing second cancer

Breast cancer survivors who are overweight have a statistically significant increased risk of developing second primary cancers, according to results from a study conducted by Kaiser Permanente researchers and published in the Journal of the National Cancer Institute. There are approximately 3.9 million breast cancer survivors in the United States today and studies have found women diagnosed with breast cancer […]

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New genetic link to male infertility found

The findings published in eLife show that men with this unstable subtype of the Y chromosome have a significantly increased risk of genomic rearrangements. These rearrangements affect the sperm production process (spermatogenesis) and consequently, these men can be up to nine times more likely to have fertility issues. Molecular diagnostics of this genetic variant could help identify those at higher […]

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New genetic link to male infertility found

The findings published in eLife show that men with this unstable subtype of the Y chromosome have a significantly increased risk of genomic rearrangements. These rearrangements affect the sperm production process (spermatogenesis) and consequently, these men can be up to nine times more likely to have fertility issues. Molecular diagnostics of this genetic variant could help identify those at higher […]

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Rare genetic variant may explain severe COVID-19 in young healthy male patients

The novel coronavirus disease 2019 (COVID-19) pandemic has now been spreading for over a year, but several mysteries surrounding its diverse outcomes remain. How is it that some young healthy individuals contract the infection(caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and become critically unwell? Why do others, who are older and have underlying comorbidities, have less severe […]

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Researchers test novel gene regulation approach to treat brain diseases

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies. It leverages zinc finger proteins, which specifically bind to the DNA that codes for the protein Tau without altering it, thereby reducing Tau production in […]

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Pediatric cancers have unique genetic vulnerabilities

Most cancer drugs that target specific genetic mutations are designed for adult cancers rather than those in children, partly because pediatric cancers have fewer mutations. To look for more ways to target childhood cancers, researchers at the Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute and Boston Children’s Hospital decided to look for genetic dependencies in various pediatric cancers. […]

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