Machine learning’s next frontier: Epigenetic drug discovery

Machine learning’s powerful ability to detect patterns in complex data is revolutionizing how we drive, how we diagnose disease and now, how we discover new drugs. Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a machine-learning algorithm that gleans information from microscope images—allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental […]

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Epigenetic markers reveal tumor progression and metastasis in multiple cancer types

New University of Otago research into tell-tale markers of cancer cells could help doctors identify whether the cells are more likely to spread to other parts of the body. The impact of that knowledge could give doctors and patients a clearer idea of how aggressively the cancer cells spread and therefore inform treatment options. The research was published this week […]

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Ancient epigenetic changes silence cancer-linked genes

An epigenetic change, a form of DNA control, that deactivates some genes linked to cancer late in human development has been conserved for more than 400 million years, new research led by the Garvan Institute of Medical Research suggests. Researchers uncovered that genes turned on in some cancers in humans also exist in zebrafish—but are ‘silenced’ within just hours of […]

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Scientists call for unified standards in 3-D genome and epigenetic data

Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease. Properly producing and managing this large amount of data is both challenging and necessary for the progress of this field. In a perspective paper published in Nature […]

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