Legal consumption of alcohol and tobacco may increase the use of illicit drugs

The use of legal drugs (tobacco and alcohol) may lead to the use of cannabis, a new study led by the University of Bristol and published in the journal Addiction has found. The study also found evidence that cannabis use may lead to smoking initiation, and opioid dependence could lead to increased alcohol consumption. Additionally, there might be shared risk […]

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Domestic reference pricing may reduce Medicare expenditures on new drugs, study finds

Basing new drug launch prices on historical domestic data could limit manufacturers' power to set extremely high launch prices and could reduce Medicare spending on new drugs by up to 30%, according to a new white paper released today by West Health and its Council for Informed Drug Spending Analysis (CIDSA). The study is a collaboration between researchers at West […]

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Women treated with fertility drugs do not have increased breast cancer risk, study shows

Drugs routinely used during fertility treatments to release eggs do not increase the risk of developing breast cancer, new research has shown. Researchers from King's College London, in partnership with King's Fertility, analyzed studies involving 1.8 million women undergoing fertility treatments. These women were followed up in studies for an average period of 27 years and had no increase in […]

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Curcumin nanosystems could be powerful COVID-19 therapeutics

With new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging, the coronavirus disease 2019 (COVID-19) pandemic is far from over. While the global vaccine rollout has moved at an impressive speed, the search for new safe, effective, and targeted therapies is still on. Now, a new study in Biomedicine and Pharmacotherapy reviews the potential for curcumin, a natural […]

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Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University (Japan) have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure […]

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Cancer patients treated with immunotherapy at high risk of developing thrombotic complications

In a study recently published in the leading journal "Blood", Florian Moik and Cihan Ay from the Division of Hematology and Hemastasology of the Department of Medicine I of MedUni Vienna/Vienna General Hospital, working in collaboration with the Division of Oncology, the Department of Dermatology and the dispensary of Vienna General Hospital, provided preliminary data on the incidence, risk factors […]

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New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

With the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it came to light that there were no specific and highly effective preventive or therapeutic agents against this virus. The result has been an enormous amount of studies reporting the efficacy or otherwise of novel drug candidates or repurposed drugs […]

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Pill testing won’t give people a ‘green light’ to use drugs

New research from Edith Cowan University (ECU) has found pill-testing services at Western Australian music festivals would not change people’s intention to take ecstasy if they had not used the drug before, a common argument used by opponents of pill testing. The study also found people who planned to take ecstasy at the festival reported they would not consume more […]

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