Genetic data may up diagnostic efficiency for rheumatic disease

(HealthDay)—Converting genotype information into an interpretable probability value for five different inflammatory arthritis-causing diseases could potentially improve the diagnostic efficiency of rheumatic disease, according to a study published in the May 27 issue of Science Translational Medicine. Rachel Knevel, M.D., Ph.D., from Harvard Medical School in Boston, and colleagues developed a Genetic Probability tool (G-PROB) to calculate the probability of […]

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PICTURED: First US child with coronavirus and Kawasaki disease

Heartbreaking photos show California baby girl, 6 months, who is the first US child confirmed with both coronavirus and Kawasaki disease, with a full body rash and swollen hands and feet Baby Zara, 6 months, from California, was diagnosed with Kawasaki disease, a condition that causes blood vessel inflammation and can lead to heart failure On her last day in […]

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Predictive models could provide more accurate detection of early-stage Parkinson’s disease

How is your sense of smell? Do you find yourself frequently dozing off during the day or thrashing about during dreams? Often, early stage Parkinson’s disease does not present with typical motor disturbance symptoms, making diagnosis problematic. Now, neuroscientists at York University have found five different models that use these types of non-motor clinical as well as biological variables to […]

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Researchers uncover cellular mechanism involved in Krabbe disease

A group of researchers at the University at Buffalo have published a paper that clarifies certain cellular mechanisms that could lead to improved outcomes in patients with globoid cell leukodystrophy, commonly known as Krabbe disease. The paper, titled “Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction,” was published today (May 5) in the journal Neuron. […]

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Coronavirus and Kawasaki disease in children: it’s an intriguing but unproven link

Doctors in the United Kingdom and other European countries have recently reported small but increasing numbers of critically ill children with features of both Kawasaki disease and toxic shock syndrome. These are uncommon conditions affecting the blood vessels. England’s National Health Service (NHS) issued an alert to doctors as a result. These children presented with fever, severe abdominal pain and/or […]

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Traumatic childhood increases lifelong risk for heart disease, early death

Exposure to trauma and other adverse experiences during childhood increases lifelong risk for cardiovascular disease and death, regardless of a person’s health during young adulthood, new research shows. The study, published Tuesday in the Journal of the American Heart Association, found children who experienced severe adversity—such as verbal, physical or emotional abuse or living with drug or alcohol abusers—were 50% […]

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Parkinson’s disease may start in the gut

Researchers at Karolinska Institutet in Sweden and the University of North Carolina in the USA have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders. One interesting finding was that cells from the gut’s nervous system are […]

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Why the coronavirus slipped past disease detectives

In 2009 the U.S. government launched a program to hunt for unknown viruses that can cross from animals to humans and cause pandemics. The project, called PREDICT, was funded by the U.S. Agency for International Development, and it worked with teams in 31 countries, including China. It was just one part of an emerging global network for infectious-disease surveillance. Despite […]

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Experimental medication to prevent heart disease may treat chemo-resistant ovarian cancer

Most ovarian cancer starts in fallopian tubes. Then it sloughs from its site of origin and floats around in fluid until finding new sites of attachment. It’s not easy for cancer cells to survive away from their moorings. Observations by ovarian cancer doctors at University of Colorado Cancer Center and elsewhere hint at how they might do it: These doctors […]

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Researchers propose new disease classification system for obesity

Researchers are proposing a new scientifically correct and medically actionable disease classification system for obesity, according to a paper published online in Obesity, the flagship journal of The Obesity Society. The proposed disease classification system is based on the concept Adiposity-Based Chronic Disease (ABCD). The diagnostic term reflects both the pathophysiology and clinical impact of obesity as a chronic disease. […]

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