Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University (Japan) have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure […]

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Long-COVID-19 is a significant risk in recovered patients post-hospitalization

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen, has claimed the lives of over 2.79 million people worldwide. However, the long-term effects of the virus on human health and lifespan are less well known. A new study, which appeared in the British Medical Journal, reports on a retrospective study to […]

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Rare genetic variant may explain severe COVID-19 in young healthy male patients

The novel coronavirus disease 2019 (COVID-19) pandemic has now been spreading for over a year, but several mysteries surrounding its diverse outcomes remain. How is it that some young healthy individuals contract the infection(caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and become critically unwell? Why do others, who are older and have underlying comorbidities, have less severe […]

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Drinking flavanol-rich cocoa could protect from mental stress-induced cardiovascular events

Increased consumption of flavanols – a group of molecules occurring naturally in fruit and vegetables – could protect people from mental stress-induced cardiovascular events such as stroke, heart disease and thrombosis, according to new research. Researchers have discovered that blood vessels were able to function better during mental stress when people were given a cocoa drink containing high levels of […]

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Racial disparities in heart disease, hypertension, and diabetes death rates

In the last 20 years, Black adults living in rural areas of the United States experienced high mortality rates due to diabetes, high blood pressure, heart disease and stroke compared to white adults. According to a research letter published in the Journal of the American College of Cardiology, racial disparities improved minimally in rural areas over the last two decades, […]

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High obesity rates in Southern states magnify Covid threat

In January, as Mississippi health officials planned for their incoming shipments of Covid-19 vaccine, they assessed the state's most vulnerable: health care workers, of course, and elderly people in nursing homes. But among those who needed urgent protection from the virus ripping across the Magnolia State were 1 million Mississippians with obesity. Obesity and weight-related illnesses have been deadly liabilities […]

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Multiethnic study informs cancer risk, diabetes reduction strategies

A possible key to high incidence of type-2 diabetes among Japanese Americans has been uncovered using data from the most ethnically diverse and longstanding study in the world, the University of Hawaiʻi Cancer Center’s Multiethnic Cohort (MEC) Study. The development of type-2 diabetes has been linked to visceral adipose tissue (VAT) or intra-abdominal fat, particularly in Japanese Americans with ectopic […]

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SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation. Moreover, they observe that the severity of coronavirus disease 2019 (COVID-19) primarily depends on the blood […]

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