Antidepressant Shines in Phase 2 Trial, but FDA Voices Concerns

Although a novel investigational drug that combines dextromethorphan and bupropion (AXS-05, Axsome Therapeutics) met its primary and key secondary endpoints in a phase 2 trial of patients with treatment-resistant depression (TRD), the US Food and Drug Administration (FDA) has voiced some concerns. In the MERIT study, AXS-05 significantly delayed time to depression relapse compared with placebo (primary endpoint) — with […]

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Internet CBT for depression reviewed and analyzed

Internet-based cognitive behavioral therapy (CBT) for depression is often just as effective as traditional CBT. This is clear from an international study involving scientists at the University of Gothenburg. However, some online treatments have components that can be harmful. Internet CBT (iCBT) as a method of delivering treatment is on the increase. Nevertheless, it has been unclear to date which […]

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Poor workplace psychological health and safety can increase risk of depression symptoms

A year-long Australian population study has found that full time workers employed by organizations that fail to prioritize their employees' mental health have a threefold increased risk of being diagnosed with depression. And while working long hours is a risk factor for dying from cardiovascular disease or having a stroke, poor management practices pose a greater risk for depression, the […]

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Depression, tau deposits seen in subset of middle-aged persons

Middle-aged people with depressive symptoms who carry a genetic variation called apolipoprotein (APOE) ε4 may be more at risk to develop tau protein accumulations in the brain’s emotion- and memory-controlling regions, a new study by researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) and collaborating institutions suggests. The Journal of Alzheimer’s Disease […]

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How Telehealth Is Making It Easier to Keep That Therapy Session

  When the covid-19 pandemic forced behavioral health providers to stop seeing patients in person and instead hold therapy sessions remotely, the switch produced an unintended, positive consequence: Fewer patients skipped appointments. This story also ran on NBC News. It can be republished for free. That had long been a problem in mental health care. Some outpatient programs previously had […]

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Psychosis, Depression Tied to Neurodegeneration in Parkinson’s

Depression and psychosis are significantly associated with neuronal loss and gliosis – but not with Lewy body scores – in Parkinson’s disease, data from analyses of the brains of 175 patients suggest. Previous research has suggested a link between neuronal loss and depression in Parkinson’s disease (PD) but the impact of Lewy bodies has not been well studied, Nicole Mercado […]

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Whitney Port Needs 'Me-Time' to Keep Anxiety & Depression at Bay

Practicing self-care is not easy for busy moms who have been taught to consider the act selfish. This is why Whitney Port’s recent Instagram post during Mental Health Awareness Month is important to help fellow moms view self-care as absolutely necessary, not indulgent. Related story John Legend Warns New Dads About Those Early Postpartum Days Port herself felt she had […]

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No Link Found Between Epidural Use and Autism

Exposure to epidural analgesia during labor did not show a link to a later diagnosis of autism spectrum disorder (ASD) in a population-based cohort study published April 19 in JAMA Pediatrics. Though the initial analysis showed an association, adjustment for a wide range of demographic, medical, and birth factors eliminated the link. The authors note that their findings contrast with […]

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Study: Spanking May Change Children’s Brains

Rare is the parent who’s never so much as thought about spanking an unruly child. But a new study provides another reason to avoid corporal punishment: Spanking may cause changes in the same areas of a child’s brain affected by more severe physical and sexual abuse. Previous research has consistently found links between spanking and behavioral problems, aggression, depression, and […]

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New Global Telepsychiatry Guidelines Released

The World Psychiatric Association (WPA) has released new global telemedicine guidelines. Prompted by the worldwide explosion of interest in telepsychiatry driven by the COVID-19 pandemic, the guidelines emphasize the need for international collaboration in psychiatry. “Global teamwork is the light at the end of the tunnel” of the current crisis, lead authors Davor Mucic, MD, The Little Prince Treatment Center, […]

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