TB study reveals potential targets to treat and control infection

Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency. Co-led […]

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RNA quality control system goes awry in frontotemporal lobar degeneration

Researchers at Osaka University have identified a fault in the RNA quality control system of cells that leads to the haywire production of toxic proteins in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD/ALS). Their new study, published in the EMBO Journal, shows that an abnormality of the C9orf72 gene produces toxic proteins that hinder the cells’ ability to destroy […]

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Higher rates of pain, bleeding found with Essure birth control device

(HealthDay)—The permanent birth control device Essure is associated with higher rates of chronic lower abdominal or pelvic pain and abnormal uterine bleeding compared with tubal ligation, according to interim results of a postmarket study ordered by the U.S. Food and Drug Administration. The researchers compared Essure and tubal ligation among more than 1,100 women across the United States and found […]

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Two enzymes control liver damage in NASH, study shows

As much as 12 percent of adults in the United States are living with nonalcoholic steatohepatitis (NASH), an aggressive condition that can lead to cirrhosis or liver cancer. After identifying a molecular pathway that allows NASH to progress into liver cell death, University of California San Diego School of Medicine researchers were able to halt further liver damage in mouse […]

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Effort to control opioids in an ER leaves some sickle cell patients in pain

India Hardy has lived with pain since she was a toddler—ranging from dull persistent aches to acute flare-ups that interrupt the flow of her normal life. The pain is from sickle cell disease, a group of genetic conditions that affect about 100,000 people in the U.S., many of them of African or Hispanic descent. Sitting in the afternoon heat on […]

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New technology allows control of gene therapy doses

Scientists at Scripps Research in Jupiter have developed a special molecular switch that could be embedded into gene therapies to allow doctors to control dosing. The feat, reported in the scientific journal Nature Biotechnology, offers gene therapy designers what may be the first viable technique for adjusting the activity levels of their therapeutic genes. The lack of such a basic […]

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Molecular control of neurotransmitter linked to autism described

Many neurodevelopmental disorders such as epilepsy, schizophrenia, and autism have been linked to disruption of the key neurotransmitter GABA, but the underlying causes of the disruptions have been difficult to pinpoint. In two new papers published Oct. 15 in Science Signaling, researchers from Yale, France, Japan, and the United Kingdom have zeroed in on a molecular mechanism crucial to normal […]

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Birth control pills and teen depression possibly linked, study suggests

Fox News Flash top headlines for Oct. 4 Fox News Flash top headlines for Oct. 4 are here. Check out what’s clicking on Foxnews.com Teenage girls may be more prone to depression if they take birth control pills, a new study suggests. In a report published Wednesday in JAMA Psychiatry, teenage girls — specifically 16-year-olds — who took birth control pills reported […]

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Lipid produced by organism helps control blood sugar

Researchers based in Brazil, the United States and Germany have discovered that 12-HEPE, a lipid produced in response to cold by brown adipose tissue in the human body, helps reduce blood sugar. The results of their experiments with mice pave the way for new treatments for diabetes. The group also observed that a drug used to treat urinary dysfunction increases […]

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Blood pressure and glucose control may prevent common arrhythmia

Blood-pressure and glucose control may be effective in preventing heart block, a common form of arrhythmia, and the subsequent need for a pacemaker, according to a study by researchers at UC San Francisco. In an analysis of more than 6,000 Finnish patients, appearing online May 24, 2019, in JAMA Network Open, UCSF researchers found that more than half of the […]

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