Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University (Japan) have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure […]

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Study offers localized treatment direction for a cause of Crohn's disease

People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects. New research from the lab of Mark Sundrud, PhD, at Scripps Research, Florida suggests a more targeted treatment approach is possible. Crohn's disease develops from chronic inflammation in […]

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Forty-three percent of melanoma patients have chronic complications from immunotherapies

Chronic side effects among melanoma survivors after treatment with anti-PD-1 immunotherapies are more common than previously recognized, according to a study published March 25 in JAMA Oncology. The chronic complications, which occurred in 43% of patients, affected the joints and endocrine system most commonly, and less often involved salivary glands, eyes, peripheral nerves and other organs. These complications may be […]

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Physical comorbidity is associated with high psychological distress

Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. The analysis included 484 patients who reported a cancer diagnosis and 484 matched controls without a history of cancer. Compared with controls, patients with cancer […]

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FDA Approves Pediatric Indication for Xeomin (incobotulinumtoxina) for the Treatment of Chronic Sialorrhea

RALEIGH, N.C., December 21, 2020 — Merz Therapeutics announced today that the U.S. Food and Drug Administration (FDA) has approved a supplemental Biologics License Application (sBLA) for Xeomin (incobotulinumtoxinA) for the treatment of patients aged 2 years and older with chronic sialorrhea, or drooling. Xeomin is the first and only FDA-approved neuromodulator with this indication and was granted a priority review […]

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Imagine Dragons' Dan Reynolds Reflects on His AS Diagnosis and Chronic Pain

Not backing down. For years, Imagine Dragons frontman Dan Reynolds has been suffering from chronic pain due to ankylosing spondylitis — but he hasn’t let the condition break his stride. The Grammy-nominated musician looked back at his journey to discovering the source of his back pain in an exclusive interview with Us Weekly while discussing his work with the Monster […]

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Disparities Seen in Internet Access for Those With Chronic Conditions

MONDAY, Nov. 9, 2020 — There are disparities in access to the internet among those with chronic health conditions such as hypertension and diabetes, according to a research letter published online Nov. 2 in Diabetes Care. Vardhmaan Jain, M.D., from the Cleveland Clinic Foundation, and colleagues analyzed data from the 2016 to 2017 Behavioral Risk Factor Surveillance System to assess […]

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Reduced Drinking May Improve Veterans’ Chronic Pain

FRIDAY, Oct. 9, 2020 — Cutting back on booze may reduce chronic pain and use of other substances among U.S. veterans who are heavy drinkers, according to a new report. The study included about 1,500 veterans who completed annual surveys between 2003 and 2015, and reported heavy drinking in at least one of those surveys. “We found some evidence for […]

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Fat crystals trigger chronic inflammation

A congenital disorder of the fat metabolism can apparently cause chronic hyperreaction of the immune system. This is the conclusion reached by researchers from the University of Bonn in a recent study. The results are published in the journal Autophagy. Some individuals suffer from a genetic defect that causes their cells to form an unusual kind of fat. The consequences […]

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