Delivering immune-stimulating nanoparticles to the lungs via red blood cells halts metastatic tumor growth in mice

When a patient with cancer is told the devastating news that their disease has spread, or metastasized, to a new part of their body, it has most often moved to their lungs. The branching blood vessels that allow oxygen to diffuse from the lungs’ air sacs into red blood cells are so tiny that a rogue cancer cell circulating in […]

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When malaria parasites trick liver cells to let themselves in

A new study led by Maria Manuel Mota, group leader at Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal), now shows that malaria parasites secrete the protein EXP2 to make their entry into hepatocytes. These findings, published today in the scientific journal Nature Communications, open a new avenue for prophylactic anti-malarial strategies, since blocking or decreasing the infection of […]

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Fighting Zika? Call in the T cells

Where Aedes mosquitoes fly, Zika virus may not be far behind. Although the explosive 2015-2016 Zika epidemics in the Americas are behind us, Zika may re-emerge, and “in many countries, Zika may be spreading in silence,” says Sujan Shresta, Ph.D., a professor at La Jolla Institute for Immunology (LJI). “We need to develop effective vaccines.” In a new Science Advances […]

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Cigarette smoke can reprogram cells in your airways, causing pulmonary disease to hang on after smoking ends

Smoking is the most common cause of chronic obstructive pulmonary disease, an often fatal respiratory condition that afflicts millions of Americans. But for many patients living with COPD, stopping smoking isn’t the end of the battle. Cigarette smoke is a complex mixture of gasses, chemicals and even bacteria. When it enters the lungs, it generates an inflammatory response much like […]

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Researchers create human airway stem cells from patients’ cells

For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium in response to injury, this study may help accelerate research on diseases impacting the […]

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Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function

Ultraviolet B (UVB) is used as an effective therapy for individuals with psoriasis and atopic dermatitis because it has an immunosuppressive effect. The immune system develops to protect the body from infection or cancer. Its activation affects many physiological functions. Regulatory T (Treg) cells, expressing CD25 and Foxp3, constitute about 5-10% of peripheral CD4+T cells and work as brake on […]

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Researchers pinpoint hierarchy of breast cancer cells as potential cause for treatment resistance

You might have heard the old proverb, “It takes a village to raise a child.” University of Cincinnati instructor Syn Yeo, Ph.D., thinks the same analogy applies when it comes to cells and the growth of cancer, particularly breast cancer. In his recent study, published in the journal eLife, Yeo, research instructor in the department of cancer biology at the […]

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Study finds fatty acid that kills cancer cells

Researchers have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells. The study, published in Developmental Cell on July 10, found that DGLA can induce ferroptosis in an animal model and in actual human cancer cells. Ferroptosis is an iron-dependent type of cell death that was discovered in recent years and has become a […]

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Brain cells can harbor and spread HIV virus to the body

Researchers have found that astrocytes, a type of brain cell can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs. HIV moved from the brain via this route even when the virus was suppressed by combination antiretroviral therapy (cART), a standard treatment for HIV. The study, conducted by researchers […]

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Scientists modify CAR-T cells to target multiple sites on leukemia cells

In a new pre-clinical study published this week in the journal Leukemia, the research team of Children’s Hospital Los Angeles investigator Hisham Abdel-Azim, MD, MS, worked with colleagues to engineer T-cells to identify and target multiple sites on acute lymphoblastic leukemia cells instead of just one. The early collaboration points the way to future clinical trials to test the therapy. […]

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