Scientists turn into molecular detectives to find clues to why certain cancer therapies stop working

A new research study at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) turns cancer scientists into molecular detectives, searching for clues for why certain cancers are able to spread and evolve by studying tissues collected within hours of death. Led by Dr. Sameek Roychowdhury, this […]

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Researchers discover new pathway that makes drugs less effective in bowel cancer patients

Leading scientists at the University of Birmingham have discovered a previously unknown pathway that prevents specific drugs from working in patients with bowel cancer. The research findings pave the way for increasing the number of bowel cancer patients who can be successfully treated, say the scientists. Bowel cancer, also called colorectal cancer, affects the large bowel, which is made up […]

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New insights could help unlock the mystery of how lung cancer arises in never smokers

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body. This study was conducted by an international team led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and […]

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Hormones play a vital role in the development of breast cancer

A study by RCSI University of Medicine and Health Sciences has provided greater insight into the role that hormones play in the development of breast cancer in patients. The novel findings could enhance the treatment for breast cancer, assisting clinicians in optimising individual patient care and improving overall survival rates for patients. The study entitled "Steroid Ligands, the Forgotten Triggers […]

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High cholesterol fuels cancer by fostering resistance to a form of cell death

Chronically high cholesterol levels are known to be associated with increased risks of breast cancer and worse outcomes in most cancers, but the link has not been fully understood. In a study appearing online Aug. 24 in the journal Nature Communications, a research team led by the Duke Cancer Institute has identified the mechanisms at work, describing how breast cancer […]

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Mount Sinai awarded more than $4 million to evaluate anal cancer screening in high-risk women

The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million by the National Cancer Institute for a large-scale study to evaluate anal cancer screening in high-risk women who have been previously diagnosed with human papillomavirus (HPV) infection. This multi-center study is a collaboration between the Mount Sinai Anal Dysplasia Screening Program, The […]

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Cervical cancer rates stable or trending down in countries with effective screening measures

A recent trend analysis indicates that cervical cancer incidence and mortality rates have remained stable or are dropping in most countries across the globe. These rates differ based on each country’s socioeconomic development level, cervical cancer screening use, and human papillomavirus (HPV) vaccination rates. The findings are published by Wiley early online in Cancer, a peer-reviewed journal of the American […]

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Cancer treatments didnt falter in Australia during 2020 COVID-19 lockdowns

Australian cancer patients kept up their pharmaceutical treatments during last year’s COVID-19 lockdowns, a big data study from UNSW Sydney shows.  The findings, published today in Lancet Regional Health—Western Pacific, come as a relief following early concerns that cancer patients would decrease, or even stop, potentially life-saving treatments during the pandemic.  But the researchers say the good news is closely […]

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Drug combination could make curative surgery possible for some liver cancer patients

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates. Results published July 29 in the journal Nature Cancer by researchers at the Johns Hopkins Kimmel Cancer Center describe the benefits of this drug combination. Among 15 people with hepatocellular […]

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