Immune properties in ancient DNA found in isolated villages might benefit humanity today

Could remnants of DNA from a now extinct human subspecies known as the Denisovans help boost the immune functions of modern humans? An international study co-led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and published in the scientific journal PLOS Genetics, represents the first characterizations of genes in the DNA of healthy individuals from […]

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Starting estradiol therapy soon after menopause may benefit arteries

Taking estradiol within 6 years after the onset of menopause may help prevent atherosclerosis, plaque buildup in artery walls, from progressing; however, starting estradiol therapy ten years after menopause did not have similar benefits, according to preliminary research presented at the American Heart Association’s Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2020. Estradiol is a female sex […]

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Women older than 75 may not reap death benefit from continued mammography screening

Healthy women over the age of 75 years might not benefit from continuing breast cancer screening. Researchers used data from the Medicare program to estimate the risk of breast cancer mortality under two strategies: continuing versus stopping screening in older women. They found a small mortality benefit for continuing to screen women between the ages of 70 to 74, but […]

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People with obesity who experience self-directed weight shaming benefit from intervention

People with obesity are often treated with less respect than other people, discriminated against, and socially devalued because of their weight. This societal stigma can sometimes be internalized, leading individuals with obesity to blame and devalue themselves because of their weight. While it’s known that weight “self-stigma” is associated with poor mental and physical health, little is known about how […]

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High-dose erythropoietin no benefit for extreme preemies

(HealthDay)—For extremely preterm infants, high-dose erythropoietin treatment from 24 hours after birth does not result in a reduced risk for severe neurodevelopmental impairment or death at age 2 years, according to a study published in the Jan. 16 issue of the New England Journal of Medicine. Sandra E. Juul, M.D., Ph.D., from the University of Washington in Seattle, and colleagues […]

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A machine learning-based algorithm to predict which cancer patients benefit from immunotherapy

Scientists at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with the Centre for Genomic Regulation (CRG) and Radboud University, have developed an algorithm that can predict which cancer patients are more likely to benefit from immunotherapy. Mutations in our DNA can disrupt protein synthesis, sometimes causing truncated proteins which don’t work as intended. Known as nonsense mutations, […]

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New research suggests proton radiation can benefit pts with challenging liver tumors

Two new studies support and inform the use of proton radiation therapy to treat patients with hepatocellular carcinoma (HCC), a common but often fatal type of liver cancer for which there are limited treatment options. One study (Sanford et al.) suggests that proton radiation, compared to traditional photon radiation, can extend overall survival with reduced toxicity. A second study (Hsieh […]

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New WHO autoantibody reference reagent will benefit SLE patients

Reference reagents are important in diagnostics and care of patients with systemic lupus erythematosus (SLE). In a new study, an international team of researchers presents a new WHO autoantibody reference reagent that will help to align autoantibody analyses and thus to optimize diagnosis and treatment to patients irrespective of where they live. The findings are published in Annals of the […]

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COPD, ILD patients may not benefit from bilateral lung transplant listing

(HealthDay)—While an unrestricted listing strategy does not seem to impact overall survival among patients with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD) awaiting lung transplant, it may increase the number of transplants performed, according to a study published in the February issue of the Annals of the American Thoracic Society. Michaela R. Anderson, M.D., from the Columbia […]

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