Another promising approach for hard-to-treat blood cancers

For patients with some hard-to-treat blood cancers, a simple “off-the-shelf” immunotherapy is achieving promising results. A clinical trial of the developmental drug Glofitamab has shown it can produce a durable “complete response”—meaning the cancer became undetectable—in patients with relapsed or treatment resistant B-cell lymphomas. One option for these patients is CAR T-cell therapy—also an immunotherapy but one which involves collecting […]

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Another promising approach for hard-to-treat blood cancers

For patients with some hard-to-treat blood cancers, a simple “off-the-shelf” immunotherapy is achieving promising results. A clinical trial of the developmental drug Glofitamab has shown it can produce a durable “complete response”—meaning the cancer became undetectable—in patients with relapsed or treatment resistant B-cell lymphomas. One option for these patients is CAR T-cell therapy—also an immunotherapy but one which involves collecting […]

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Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests

An innovative approach to treating bone tumors—starving cancer cells of the energy they need to grow—could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. Studying human cancer cells and mice, the researchers said that a two-drug combination […]

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Alternative cancer cell fuel source targeted as therapeutic approach for breast cancer

Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in conditions of low nutrient and oxygen availability. This molecule caused tumor growth inhibition and regression in preclinical studies, demonstrating the promise of this approach as a novel therapeutic strategy for solid tumors. Study results were […]

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Novel therapy approach for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine. The novel approach utilizes receptor-targeted photodynamic therapy with exendin-4-IRDye700DX to induce phototoxicity in insulin-producing cells that cause hyperinsulinemic hypoglycemia. Insulin production by pancreatic beta cells is […]

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6 months after New Zealand’s first COVID-19 case, it’s time for a more strategic approach

Today marks six months since New Zealand’s first COVID-19 case was identified on February 26. So far New Zealand has been largely in reactive mode, initially during the first elimination stage which finished in early June and now in response to the ongoing Auckland outbreak. Given the vigorous response to controlling this current cluster, we have a good chance of […]

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Researchers find promising new treatment approach for multiple sclerosis

In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report. The findings, published online today by Science Translational Medicine, could lead to a new treatment strategy for this neurological disease and other conditions marked […]

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Researchers develop novel approach to capture hard-to-view portion of colon in 3D

In a groundbreaking discovery, researchers at Children’s Hospital of Philadelphia (CHOP) developed a new imaging method that allows scientists to view the enteric nervous system (ENS) – a key part of the human colon—in three dimensions by making other colon cells that normally block it invisible. The ENS has previously only been visible in thin tissue slices that provide limited […]

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Study shows promising new web approach to prevent firearm suicide

Access to firearms and other lethal methods of suicide during periods of risk can make it more likely that a suicide attempt will end in death. Yet many patients with suicidal thoughts or behaviors receive no counseling about this from healthcare providers, and many have questions about options for firearm or medication storage. To address the issue, clinicians and researchers […]

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Blue light triggers memory and emphatic fear in mice via noninvasive approach

Researchers at the Center for Cognition and Sociality, within the Institute for Basic Science (IBS) in South Korea, have engineered an improved biological tool that controls calcium (Ca2+) levels in the brain via blue light. Published in Nature Communications, this optogenetic construct, called monster-OptoSTIM1 or monSTIM1 for short, causes a change in mice’s fear learning behavior without the need of […]

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