‘Rogue’ antibodies found in brains of teens with delusions and paranoia after COVID-19

Two teens developed severe psychiatric symptoms such as paranoia, delusions and suicidal thoughts during mild COVID-19 infections. Now, scientists think they’ve identified a potential trigger: Rogue antibodies may have mistakenly attacked the teens’ brains, rather than the coronavirus.   The researchers spotted these rogue antibodies in two teens who were examined at the University of California, San Francisco (UCSF) Benioff […]

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COVID-19 vaccination induces transient increase in cellular and antibody responses to S1 antigenic sequence

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, is an RNA virus belonging to the family Coronaviridae. This virus is highly virulent with a greater transmission rate and causes mild to severe symptoms. This virus has infected around 238 million individuals and claimed more than 4.8 million lives worldwide. Study: Cellular […]

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Autoimmune antibodies strongly linked to the severity of illness in COVID-19 patients

The presence of special immune system defense molecules, called autoimmune antibodies, has been strongly tied to how poorly people fare when hospitalized with COVID-19, a new study shows. Led by researchers at NYU Grossman School of Medicine, the study detected the autoimmune antibodies in the blood of more than a third of men and women on admission to hospital and […]

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SARS-CoV-2 Spike may trigger production of antibodies that cross-react with human thrombopoietin to induce thrombocytopenia

Scientists have stated that molecular mimicry between human proteins and pathogens can incorrectly lead to antibodies attacking human proteins. Such an occurrence can cause transient or chronic autoimmune disorders. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected individuals often suffer from thrombocytopenia, a condition associated with low platelet counts. The cytokine thrombopoietin regulates platelet count. Previous studies have reported that thrombocytopenia […]

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Amid covid booster debate, West Virginia to check immunity of vaccinated nursing home residents

West Virginia raced ahead of the country last winter to get people in nursing homes vaccinated against covid-19, but with cases and hospitalizations on the rise again, state officials want to know whether immunity levels are falling for residents who had their shots. Starting in August, the state plans to begin measuring the levels of disease-fighting antibodies in the blood […]

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Fungi and bacteria in the gut may equally impact human health and disease severity

The gut microbiome has received a lot of attention, but new research shows that fungi in the gut are also an important microorganism in gut functioning and health, which then affects human health. Gut Health. Image Credit: metamorworks/Shutterstock.com Contrasting effects of fungal communities in the gut In recent years, the role of microbial diversity and richness in the gut has […]

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Study reports on the immunogenicity of single-shot COVID-19 vaccine against SARS-CoV-2 variants

In the three months since Johnson & Johnson's COVID-19 vaccine received emergency use authorization from the U.S. Food and Drug Administration, more than 10 million Americans have received the vaccine, according to the Centers for Disease Control and Prevention. The single-shot viral vector vaccine — developed in collaboration with Beth Israel Deaconess Medical Center (BIDMC) immunologist Dan Barouch, MD, PhD […]

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SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

Once a virus infects a cell, neighboring cells are likely to become infected by interactions that are dependent on the cell and the virus in question. For example, cell-to-cell spread is facilitated in HIV by viral synapses, which also allow for escape from neutralizing antibodies. Low-level drug inhibitors are able to suppress infection if applied before the first cell is […]

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Immune tolerance in hemophilia can be modulated by B cell activating factor

A group of scientists have just made a key discovery that could prevent and eradicate immune responses that lead to treatment failure in about one-third of people with severe hemophilia A. Hemophilia is the most common severe inherited bleeding disorder in men. The disease affects 1 in 10,000 males worldwide and results from deficiency of blood clotting factor VIII (FVIII). […]

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Antibody tests, even rapid finger pricks, are effective COVID-19 screening tools

New findings from a Michigan Medicine study reveal that antibody testing is predictive of prior COVID-19 infection, and rapid screening methods – even from finger pricks – are effective testing tools. Researchers analyzed antibody tests conducted on more than 500 subjects in patient care settings. They found that people who had COVID, including those with mild symptoms, produced antibodies. "For […]

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