UNLV neuroscientists bolster the connection between Type II diabetes and Alzheimer's disease

A team of UNLV neuroscientists has strengthened the link between Type II diabetes and Alzheimer's disease. In a study published in the September issue of the journal Communications Biology, researchers show that chronic hyperglycemia impairs working memory performance and alters fundamental aspects of working memory networks. Diabetes is a major risk factor for developing Alzheimer's disease, but it is not […]

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Zero Benefit of Aducanumab for Alzheimers Disease, Panel Rules

An influential, independent panel unanimously voted that aducanumab (Aduhelm) offers no benefit for patients with Alzheimer’s disease (AD), adding to growing opposition from medical experts to the US Food and Drug Administration’s (FDA’s) approval of this controversial drug. The Institute for Clinical and Economic Review (ICER) asked one of its expert panels, the California Technology Assessment Forum, to consider the […]

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‘Precision’ Nutrition? DHA Benefit Modified by AD Genetic Risk

In cognitively unimpaired middle-aged adults at high genetic risk for Alzheimer’s disease (AD), higher intake of dietary docosahexaenoic acid (DHA) was associated with greater resistance to disease-related brain atrophy on neuroimaging.    DHA intake, measured using a food frequency questionnaire, was found to be significantly related to greater cortical thickness, the AD signature in individuals homozygous for APOE-ε4, that is […]

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RSNA: Anxiety May Hasten Progression to Alzheimer Disease

WEDNESDAY, Nov. 25, 2020 — Apolipoprotein E4 (ApoE4) genotype, anxiety, and lower hippocampal (HV) and entorhinal cortex volumes (ERV) are associated with an elevated progression rate from mild cognitive impairment (MCI) to Alzheimer disease (AD), according to a study scheduled for presentation at the annual meeting of the Radiological Society of North America, held virtually from Nov. 29 to Dec. […]

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More hospital days seen with antipsychotic use in Alzheimer disease

(HealthDay)—Alzheimer disease patients who initiate treatment with antipsychotic medications spend more days hospitalized than those who do not initiate antipsychotics, according to a study recently published in the Journal of Post-Acute and Long-Term Care Medicine. Marjaana Koponen, Ph.D., of the Kuopio Research Center of Geriatric Care at the University of Eastern Finland, and colleagues used a nationwide exposure-matched cohort to […]

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You Got a Brain Scan at the Hospital. Someday a Computer May Use It to Identify You.

Thousands of people have received brain scans, as well as cognitive and genetic tests, while participating in research studies. Though the data may be widely distributed among scientists, most participants assume their privacy is protected because researchers remove their names and other identifying information from their records. But could a curious family member identify one of them just from a […]

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Ocular protein levels may be useful for Alzheimer testing

(HealthDay)—Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor, according to a study published March 8 in the Journal of Alzheimer’s Disease. Lauren M. Wright, M.D., from the Boston University School of Medicine, and colleagues analyzed vitreous humor samples from 80 eyes of 80 individuals to quantify levels of beta amyloid-β (Aβ40, […]

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