Clostridial diarrhea due to antibiotics

Antibiotics köcan infection with the gefäannual intestinal bacterium begüother. The consequences are sometimes life-threatening. But there will always be more treatment options available to Verfüaside

Taking an antibiotic can f&uuml to a clostridia infection;hren. The consequences are bloody Durchfälle and fever

A therapy that is supposed to heal and save lives, does exactly the opposite: This can sometimes happen if antibiotics are used. Because of this important discovery of the medicine and a sharp weapon against pathogens is preparing möperhaps a gefäannual bacterium. The funds beschäwalk-in from trillions of bacteria-existing healthy intestinal flora – a so far inevitable side effect.

A bacterium, however, köcan antibiotics often harm them: the germ Clostridium difficile (CD). In some people, he has been living undetected in the intestine. This is not a bad thing, as long as the other bacteria keep it in check. But if these die due to antibiotic-therapy, can make CD wide. 

CD-infections fülisten to bloody Durchfäcases and fever

The gefäannual germ excretes toxins, the bowel wall durchläcasual make. Strong, sometimes bloody diarrhea, Bauchkräspasms, and fever are mödaily follow. In addition, the bowel can be extremely aufblähen, leading to cracking, sometimes in the intestinal wall and blood poisoning führt. Then there is danger to life. Almost 2700 Todesfähell, the CD zurückführen, registered by the Federal Statistical office in the year 2015.

A recent study lässt suggests that there is still more to be köcould. Especially äolder people are gefährdet, particularly if you suffer from other disease or therapy to go through, your immune system schwächt. The duration of taking medication for heartburn (proton pump inhibitors) erhöht the risk. An antibiotic n&ouml is then;tig, makes in about a hundred Fäcases CD the patient’s problems.

The number of CD infections in hospitals is increasing

Very häoften that happens in hospitals. Where many sick people come together in a confined space, they can spread bacteria very easy. Künewly a study showed: lying in a hospital bed with a CD of Infected, erhöthis ht für the following patients, the risk of infection. Because the germs üsurvival in encapsulated Form, üalleged alcohol-containing disinfectants köcan’t touch anything. The pathogens get rid of benötransparent Krankenhäuser specific Hygiene and trained staff. Because that’s not stäfully gewäguarantees, it comes to Ausbrü.

For the last ten years, the Numbers of CD-associated infections and Sterbef&auml have;lle strong &ndash increased; especially in the USA, but also in Europe. The cause dafür the dissemination &shy is;especially infektiöser Stämme of the bacterium. An additive in Lebens­resources womöresembled The gef&auml added: ;annual Stämme köcan in contrast to other use of the sugar Trehalose as a source of energy. This is the industry, since the beginning of the Millennium, a – for example, as a natünatural frost protection in Tiefkühlkost, strawberries are about the thawing muddy.

The previous antibiotic therapy must be discontinued

After all, the particularly infekti&ouml was;se strain 027 is currently on the Rüretreat, says Professor Barbara Gärtner, Director of the Institute für Hygiene at the University hospital of the Saarland. At the same time, she warns: "It köcan any new gefäannual Stämme occur." In the treatment it is zunäto finish first, the antibiotic therapy – if möpossible.

"In mild Fäcases can nat&uuml the infection then;of course ausheilen", Professor Lutz of M&uuml says;ller, chief doctor of the Institute für laboratory medicine, Microbiology and Hygiene at the Christophorus-Kliniken in westfämetallic Coesfeld. 

But most of the time genüthe non-gt. Then, paradoxically, come back antibiotics into the game. Three of them have proved to be effective. The choice depends on the Severity of the disease process. In spite of medications, for example, each f&uuml suffers;income Affected a Rückfall, a small proportion of patients, the course is chronic. A Antiköthe body that came at the beginning of last year on the market, can prevent it sometimes. However, it is expensive, and its Effektivität lässt to wüwant übrig. "This is really the last Wahl", expert G&auml says;rtner.

In severe Fäcases: chair donation as an Alternative to antibiotics

Rather &Auml set;doctors, in the meantime, on a zunäfirst, bizarre-looking therapy: you ütransfer the stool of a healthy donor into the patient, usually through an enema. The success rate beträgt üabout 90 per cent, as studies have shown. The donation helps CD in the gut by healthy bacteria to verdrängen.

More than 50 hospitals in Germany use this form of therapy in the meantime. Scientists have now demonstrated that the chair can also be deep frozen and stored. And they have Packed the bacteria contained in the capsules, which are just as effective. Of müshot to swallow the patient, of course, a couple of dozen. 

Nevertheless, the chair donation is not a standard therapy – but an Option für patients with repeated Rückfäcases. Because the donor stool is examined for pathogens, but a residual risk remains. "You can ausschlie&szlig also not;that the gut bacteria in individual cases, chronic diseases begünstigen", Lutz of M&uuml says;ller. "Since especially in the case of jüyounger people have scruples in front of a non-critical use."

Thus, a clostridia infection develops

The intestines of healthy people is the sealing of nü- bacteria are colonized. 

Antibiotics reduce the diversity and number of these bacteria.

The Patient comes now with spores of the bacterium Clostridium difficile in contact, köcan they get into the intestines and massively multiply. They secrete toxins from the intestinal wall schäwalk-in. The result is severe diarrhea. Häoften a heavy Entz&uuml develops;making (pseudomembranöse Colitis).

The bacteria are treated with antibiotics, but spores of them köcan üsurvival.

You füdo häfrequently to re-Überhand the exception of CD in the intestine.

Antibiotic therapy achieved no success, the question comes up a chair donation. Intestinal bacteria of a healthy donor are ütransfer or in the Form of ­Capsules to be swallowed. The success rate is very high.

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