Removal of the Appendix reduces the risk of Parkinson’s disease by 20%

According to new research, after the removal of the Appendix, almost 20% reduced chance of developing Parkinson’s disease. To such conclusion scientists have come, having analysed the data of 1.6 million. The results of their study were published in the journal Science Translational Medicine.

Parkinson’s disease is a common disorder. And therefore, most likely, she may have a few points of the beginning of development. In some cases, this may be the gastrointestinal tract, in others the brain, says Vivian LaBrie (Viviane Labrie), lead author of the study from the Research Institute van Andela (Van Andel Research Institute) in Michigan, USA.

Parkinson’s disease is relatively common but incurable. Its symptoms include tremor of the fingers, hands and legs, stiffness, impaired balance, depression and gastrointestinal disorders, including constipation.

Studies have shown that symptoms of the disease in the gastrointestinal tract can begin 20 years before the emergence of movement disorders.

In the last decade it has become evident that Parkinson’s disease is not just a movement disorder. One of the most common non-motor symptoms of Parkinson’s disease – problems with the gastrointestinal tract, therefore some scientists believe that the disorder can begin there. The fact that the Appendix contains a protein, alpha-synuclein, which is known to accumulate in the brains of patients suffering from Parkinson’s disease, explains LaBrie.

To search for links between Parkinson’s disease and Appendix LaBrie and her colleagues analyzed the medical data of 1.6 million from Sweden. According to the researchers, appendectomy (removal of Appendix) is associated with a lower risk of developing Parkinson’s disease by 19.3%.

They separately examined the data of 849 patients with Parkinson’s disease and found that appendectomy was associated with delayed onset of disease on average for 3.6 years.

Alpha synuclein is a protein that doesn’t like to stay in one place. He is able to move from neuron to neuron, and it has been shown that it can travel through the body, says LaBrie. According to her, the protein can navigate through the wandering nerve, connecting the gastrointestinal tract and the brain.

When injected into the brain, it can spread from there, exerting neurotoxic effects, which ultimately can lead to Parkinson’s disease, says LaBrie.

James Beck (James Beck), chief scientific officer of the Parkinson Foundation and Professor of neurology and physiology at the Medical school at new York University (New York University School of Medicine), was named the new study is justified.

However, he said, although research shows that this disorder may begin in the gut, this does not mean that people should remove the Appendix, so they did not develop Parkinson’s disease. At the same time, he said, the study raises some important questions, such as whether a hit of protein from the gut to the brain the result of certain diseases of the gastrointestinal tract?

Kevin Mcconvey (Kevin McConway) from the British Open University (Open University) describes a study by a competent, however, criticizes the principles of the use of statistical data.

People whose Appendix was removed at an early age, on several grounds different from the people from whom the Appendix was not removed. Any of these differences can by itself be a reason to reduce the risk of Parkinson’s disease, and not directly the fact of removal of the Appendix, says Mcconvey.

Dmitry Kolesnik