Coronary heart disease risk higher with COPD
Patients with chronic obstructive pulmonary disease (COPD) are more likely to have coronary heart disease (CHD), but no specific phenotypes have a higher risk, according to a study published online April 27 in PLOS ONE.
Christina D. Svendsen, from Haukeland University Hospital in Bergen, Norway, and colleagues examined whether COPD patients have a true higher risk for CHD than people without COPD. The analysis included 347 COPD patients and 428 non-COPD controls who completed coronary computed tomography angiography (CCTA) and pulmonary CT.
The researchers found that when adjusting for sex, age, body composition, pack-years, C-reactive protein, cholesterol/blood pressure-lowering medication use, and diabetes mellitus, the risk for having significant stenosis trended higher for COPD patients versus controls. Similarly, the risk for having coronary stenosis and a calcium score (CaSc) >100 was higher in COPD patients. No variable was associated with significant stenosis among COPD patients, but the risk for CaSc >100 in COPD patients was associated with male sex, age, and statin use, after adjusting for body composition, pack-years, C-reactive protein, use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, diabetes, emphysema score, Global Initiative for Chronic Obstructive Lung Disease category, exacerbation frequency, eosinophilia, and hypoxemia.
Source: Read Full Article