Why HIV patients are more likely to develop tuberculosis: Discovery could lead to new added therapy for HIV patients

Tuberculosis and HIV — two of the world’s deadliest infectious diseases — are far worse when they occur together. Now, Texas Biomedical Research Institute researchers have pinpointed an important mechanism at work in this troubling health problem. And, their discovery could lead to a new mode of treatment for people at risk. The results were published in the Journal of […]

Read more

How to Get TB Patients to Take Their Pills? Persistent Texting and a ‘Winners Circle’

The hardest part of curing tuberculosis, doctors say, is getting patients to take all their pills every day for at least six months. Even the easiest regimens of four antibiotics can cause nausea, fevers, rashes and stomach pain. Health officials have tried many ways to persuade patients to comply, from gentle encouragement to imprisonment in locked wards. Now researchers have […]

Read more

Charcoal-based drug delivery system improves efficacy of common herpes drug

A study led by researchers from the University of Illinois at Chicago has found that combining acyclovir — a commonly prescribed topical herpes medication — with particles of activated carbon improves efficacy of the drug. This new approach allows for less frequent dosing and overall course of treatment while providing some protection from infection by the virus as well, opening […]

Read more

Scientists Discover a Cure for the Deadliest Strain of Tuberculosis

TSAKANE, South Africa — When Tsholofelo Msimango joined a clinical trial of new tuberculosis drugs, she was 20 years old and weighed just 57 pounds. Stricken with a deadly strain of tuberculosis, Ms. Msimango was terrified. She was to be transferred to Sizwe Tropical Diseases Hospital in Johannesburg. The nurses in the township here told her that it was far […]

Read more

Drug-resistant tuberculosis reversed in lab

About 1.5 million people died of tuberculosis (TB) in 2017, making it the most lethal infectious disease worldwide. A growing rise in drug-resistant TB is a major obstacle to successfully treating the illness. Now, researchers at Washington University School of Medicine in St. Louis and Umea University in Sweden have found a compound that prevents and even reverses resistance to […]

Read more

TB: Promising new drugs for old pathogen Mtb

Tuberculosis (TB), an ancient and notoriously difficult disease to treat, has killed millions through the course of human history; and the antibiotics that have been used to fight the disease in recent history are becoming less and less effective. In the face of this reality, Dennis Wright, professor of medicinal chemistry in the University of Connecticut’s Department of Pharmaceutical Sciences, […]

Read more

Drug delivery system would allow tuberculosis patients to switch from daily to monthly doses

Tuberculosis is one of the world’s deadliest infectious diseases: One-third of the world’s population is infected with TB, and more than 1 million people die from the disease every year. One reason TB is so pervasive is that treatment requires a six-month course of daily antibiotics, which is difficult for about half of all patients to adhere to, especially in […]

Read more