New evidence shows cytotoxic T cells can identify, invade, and destroy targets of large mass like T. gondii tissue cysts

CD8+ cytotoxic T lymphocytes can kill host cells infected with various microorganisms as well as single individual cancer cells through direct cell-to-cell contact, but their ability to destroy a target of large mass remains unexplored. A study in The American Journal of Pathology provided novel evidence on the capability of the immune system to eliminate large parasite-filled cysts associated with […]

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How pathogens are controlled when tissue is deprived of adequate oxygen supply

Infected tissue has a low concentration of oxygen. The body’s standard immune mechanisms, which rely on oxygen, can then only function to a limited extent. How does the immune system nevertheless manage to control bacteria under such conditions? The working groups led by PD Dr. Anja Lührmann and Prof. Dr. Jonathan Jantsch have investigated this question in collaboration with other […]

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The ‘wrong’ connective tissue cells signal worse prognosis for breast cancer patients

In certain forms of cancer, connective tissue forms around and within the tumour. One previously unproven theory is that there are several different types of connective tissue cells with different functions, which affect the development of the tumour in different ways. Now, a research team at Lund University in Sweden has identified three different types of connective tissue cells. In […]

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