Researchers create new viral vector for improved gene therapy in sickle cell disease

Researchers at the National Institutes of Health have developed a new and improved viral vector—a virus-based vehicle that delivers therapeutic genes—for use in gene therapy for sickle cell disease. In advanced lab tests using animal models, the new vector was up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than the conventional vectors currently […]

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A model for brain activity during brain stimulation therapy

Brain stimulation, where targeted electrical impulses are directly applied to a patient’s brain, is already an effective therapy for depression, epilepsy, Parkinson’s and other neurological disorders, but many more applications are on the horizon. Clinicians and researchers believe the technique could be used to restore or improve memory and motor function after an injury, for example, but progress is hampered […]

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CAR T cell therapy: On the cusp of ‘an immunotherapy revolution’?

A deeper understanding of the immune system’s role in controlling cancer has helped drive “an immunotherapy revolution,” offering hope for many patients with previously incurable cancers, including children, doctors have concluded in a new report. The assessment, from two Stanford University doctors, is part of their broader analysis on lessons learned from “the first leg of the CAR T cell […]

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Scientists develop a physical biomarker for cornea restoration therapy

Our eyes—the windows to the soul—need constant care, and as we age, they sometimes also need significant repair. The panes of these windows—the corneas—are transparent tissues that have been the focus of some of the oldest and most common transplantation surgeries. Now thanks to researchers in Kyoto, some such transplants may become even safer. The team, led by Kyoto University […]

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Proposed gene therapy for a heart arrhythmia, based on models made from patient cells

Researchers at Boston Children’s Hospital report creating the first human tissue model of an inherited heart arrhythmia, replicating two patients’ abnormal heart rhythms in a dish, and then suppressing the arrhythmia with gene therapy in a mouse model. Their work, published in two papers in the July 30 print issue of the journal Circulation, opens the possibility of developing single-dose […]

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Holes in the immune system left unrepaired despite drug therapy

If they don’t receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system. But a very small percentage of patients—0.3%—spontaneously control the virus themselves, without ART. Could an explanation lay partly in the sets of genes expressed by scarce white blood cells that recognize HIV? Yes, according to a study published in Nature Immunology and […]

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Individualized medical-nutrition therapy important in diabetes

(HealthDay)—Diabetes-focused medical nutrition therapy (MNT) is fundamental to overall diabetes management and should be adapted as needed throughout life, according to a consensus report published in the May issue of Diabetes Care. Noting that strong evidence supports the efficacy and cost-effectiveness of nutrition therapy as a component of quality diabetes care, Alison B. Evert, from the University of Washington in […]

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Doctors Use Electrical Implant to Aid Brain-Damaged Woman

More than 3 million Americans live with disabling brain injuries. The vast majority of these individuals are lost to the medical system soon after their initial treatment, to be cared for by family or to fend for themselves, managing fatigue, attention and concentration problems with little hope of improvement. On Saturday, a team of scientists reported a glimmer of hope. […]

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Is A Naturopath. An alleged miracle cure for cancer. Three Dead.

A seal closes the door of the alternative cancer center in the municipality Brüggen This Text appeared in 2016, in the star, as the accusations against Klaus R. were made public. On the occasion of the court proceedings, we publish it again online. Some updates have been made. Its home page should convey a sense of calm and Confidence: a […]

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Selumetinib Granted US Breakthrough Therapy Designation in Neurofibromatosis Type 1

1 April 2019 AstraZeneca and Merck & Co., Inc., Kenilworth, NJ, US (known as MSD outside the US and Canada) today announced that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) for the investigational MEK 1/2 inhibitor and potential new medicine selumetinib. This designation is for the treatment of pediatric patients aged three years and […]

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