Stem cells with ‘dual identity’ linked to loss of smell from sinus inflammation

In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis. Results of the study, they say, suggest that the stem cells’ ability to switch their identity to join in the […]

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Michael Schumacher’s stem cell surgery is ‘experimental’, doctor says

Could pioneering stem cell treatment offer hope for Michael Schumacher? How French surgeon drafted in for a ‘secret operation’ is at the forefront of the experimental procedure being tested on heart failure It is understood the German will be operated on by a heart specialist in Paris The procedure is thought to involve grafting stem cells onto damaged tissue An […]

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Mini-kidneys grown from stem cells provide new insights into kidney disease and potential therapies

An international team of researchers led by Nanyang Technological University, Singapore (NTU Singapore) has grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. The mini kidneys, known as kidney organoids, were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease, one […]

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Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. It’s the first time that scientists have specifically edited the genetic makeup of a specialized subset […]

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SIRT1 plays key role in chronic myeloid leukemia to aid persistence of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure. As a result, the majority of patients with chronic myeloid leukemia, or CML, require indefinite inhibitor treatment to prevent disease […]

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Stem cell differences could explain why women are more likely to develop adrenal cancer

Scientists have discovered a potential biological reason why women are more likely to develop adrenal disorders, including cancer. According to the researchers, the answer could lie in the increased turnover of hormone-producing cells found in the adrenal glands of females. The adrenal gland is a hormone producing organ that sits on top of the kidneys. The outer part, or cortex, […]

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Researcher reports skin properties that may limit cancer and aid stem cell regeneration

Two images published in a Cell Stem Cell paper in September 2018 summarize years of relentless questioning on how skin stem cells regenerate, which has driven much of the research of Valentina Greco, Ph.D., Carolyn Walch Slayman Professor of Genetics and professor of cell biology and of dermatology, and her lab members. The side-by-side images feature individual mouse cells in […]

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Delusions may stem from sticky beliefs, study finds

Delusions are one of the most common symptoms of psychosis, but little is known about what causes them. A new study from researchers at Columbia University and New York State Psychiatric Institute offers insight into the development of delusions, which could lead to better treatments for people with psychosis. The findings were published in Brain. An estimated 80-90 percent of […]

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Muscle stem cells can drive cancer that arises in Duchenne muscular dystrophy

People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have demonstrated that […]

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Study connects the genetic background of autistic spectrum disorders with stem cell dysfunction

Disorders of the autistic spectrum have been associated with hundreds of genetic variations, which have helped in identifying disturbed intracellular signalling pathways and molecular mechanisms typical to autism. Many gene mutations related to the autism spectrum disorders reside in a gene that produces a protein relevant to synapses, or is important for the connections between neurons. Gene defects linked with […]

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